About Inactive protein-arginine deiminase type-6
Inactive protein-arginine deiminase type-6 (PADI6) is a protein
from Homo sapiens identified by UniProt accession
Q6TGC4, 694 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Inactive protein-arginine deiminase type-6 |
|---|
| UniProt accession | Q6TGC4 |
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| Gene | PADI6 |
|---|
| Organism | Homo sapiens |
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| Length | 694 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (59)
Diseases linked to this target (Open Targets).
- Rare genetic female infertility · score 0.72
- Beckwith-Wiedemann syndrome · score 0.49
- mean platelet volume · score 0.33
- neurodegenerative disease · score 0.29
- appendicular lean mass · score 0.24
- cancer · score 0.23
- body height · score 0.22
- genetic disorder · score 0.19
- fetal growth restriction · score 0.18
- Short stature · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6TGC4-F1 | alphafold | PREDICTED | 85.68 | — |
Amino-acid sequence (694 residues)
MVSVEGRAMS FQSIIHLSLD SPVHAVCVLG TEICLDLSGC APQKCQCFTI HGSGRVLIDV ANTVISEKED ATIWWPLSDP TYATVKMTSP SPSVDADKVS VTYYGPNEDA PVGTAVLYLT GIEVSLEVDI YRNGQVEMSS DKQAKKKWIW GPSGWGAILL VNCNPADVGQ QLEDKKTKKV IFSEEITNLS QMTLNVQGPS CILKKYRLVL HTSKEESKKA RVYWPQKDNS STFELVLGPD QHAYTLALLG NHLKETFYVE AIAFPSAEFS GLISYSVSLV EESQDPSIPE TVLYKDTVVF RVAPCVFIPC TQVPLEVYLC RELQLQGFVD TVTKLSEKSN SQVASVYEDP NRLGRWLQDE MAFCYTQAPH KTTSLILDTP QAADLDEFPM KYSLSPGIGY MIQDTEDHKV ASMDSIGNLM VSPPVKVQGK EYPLGRVLIG SSFYPSAEGR AMSKTLRDFL YAQQVQAPVE LYSDWLMTGH VDEFMCFIPT DDKNEGKKGF LLLLASPSAC YKLFREKQKE GYGDALLFDE LRADQLLSNG REAKTIDQLL ADESLKKQNE YVEKCIHLNR DILKTELGLV EQDIIEIPQL FCLEKLTNIP SDQQPKRSFA RPYFPDLLRM IVMGKNLGIP KPFGPQIKGT CCLEEKICCL LEPLGFKCTF INDFDCYLTE VGDICACANI RRVPFAFKWW KMVP
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