About Ankyrin repeat domain-containing protein 12
Ankyrin repeat domain-containing protein 12 (ANKRD12) is a protein
from Homo sapiens identified by UniProt accession
Q6UB98, 2062 residues long.
MolForge cross-references it against 0 known binders and
93 disease associations.
Target properties
| Protein name | Ankyrin repeat domain-containing protein 12 |
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| UniProt accession | Q6UB98 |
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| Gene | ANKRD12 |
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| Organism | Homo sapiens |
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| Length | 2062 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (93)
Diseases linked to this target (Open Targets).
- total blood protein measurement · score 0.56
- neutrophil percentage of leukocytes · score 0.54
- lymphocyte percentage of leukocytes · score 0.53
- mean corpuscular hemoglobin · score 0.48
- Red cell distribution width · score 0.44
- sampling time · score 0.43
- mean corpuscular volume · score 0.38
- calcium measurement · score 0.36
- behavior · score 0.35
- educational attainment · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UB98-F1 | alphafold | PREDICTED | 41.15 | — |
Amino-acid sequence (2062 residues)
MPKSGFTKPI QSENSDSDSN MVEKPYGRKS KDKIASYSKT PKIERSDVSK EMKEKSSMKR KLPFTISPSR NEERDSDTDS DPGHTSENWG ERLISSYRTY SEKEGPEKKK TKKEAGNKKS TPVSILFGYP LSERKQMALL MQMTARDNSP DSTPNHPSQT TPAQKKTPSS SSRQKDKVNK RNERGETPLH MAAIRGDVKQ VKELISLGAN VNVKDFAGWT PLHEACNVGY YDVAKILIAA GADVNTQGLD DDTPLHDSAS SGHRDIVKLL LRHGGNPFQA NKHGERPVDV AETEELELLL KREVPLSDDD ESYTDSEEAQ SVNPSSVDEN IDSETEKDSL ICESKQILPS KTPLPSALDE YEFKDDDDEE INKMIDDRHI LRKEQRKENE PEAEKTHLFA KQEKAFYPKS FKSKKQKPSR VLYSSTESSD EEALQNKKIS TSCSVIPETS NSDMQTKKEY VVSGEHKQKG KVKRKLKNQN KNKENQELKQ EKEGKENTRI TNLTVNTGLD CSEKTREEGN FRKSFSPKDD TSLHLFHIST GKSPKHSCGL SEKQSTPLKQ EHTKTCLSPG SSEMSLQPDL VRYDNTESEF LPESSSVKSC KHKEKSKHQK DFHLEFGEKS NAKIKDEDHS PTFENSDCTL KKMDKEGKTL KKHKLKHKER EKEKHKKEIE GEKEKYKTKD SAKELQRSVE FDREFWKENF FKSDETEDLF LNMEHESLTL EKKSKLEKNI KDDKSTKEKH VSKERNFKEE RDKIKKESEK SFREEKIKDL KEERENIPTD KDSEFTSLGM SAIEESIGLH LVEKEIDIEK QEKHIKESKE KPEKRSQIKE KDIEKMERKT FEKEKKIKHE HKSEKDKLDL SECVDKIKEK DKLYSHHTEK CHKEGEKSKN TAAIKKTDDR EKSREKMDRK HDKEKPEKER HLAESKEKHL MEKKNKQSDN SEYSKSEKGK NKEKDRELDK KEKSRDKESI NITNSKHIQE EKKSSIVDGN KAQHEKPLSL KEKTKDEPLK TPDGKEKDKK DKDIDRYKER DKHKDKIQIN SLLKLKSEAD KPKPKSSPAS KDTRPKEKRL VNDDLMQTSF ERMLSLKDLE IEQWHKKHKE KIKQKEKERL RNRNCLELKI KDKEKTKHTP TESKNKELTR SKSSEVTDAY TKEKQPKDAV SNRSQSVDTK NVMTLGKSSF VSDNSLNRSP RSENEKPGLS SRSVSMISVA SSEDSCHTTV TTPRPPVEYD SDFMLESSES QMSFSQSPFL SIAKSPALHE RELDSLADLP ERIKPPYANR LSTSHLRSSS VEDVKLIISE GRPTIEVRRC SMPSVICEHT KQFQTISEES NQGSLLTVPG DTSPSPKPEV FSNVPERDLS NVSNIHSSFA TSPTGASNSK YVSADRNLIK NTAPVNTVMD SPVHLEPSSQ VGVIQNKSWE MPVDRLETLS TRDFICPNSN IPDQESSLQS FCNSENKVLK ENADFLSLRQ TELPGNSCAQ DPASFMPPQQ PCSFPSQSLS DAESISKHMS LSYVANQEPG ILQQKNAVQI ISSALDTDNE STKDTENTFV LGDVQKTDAF VPVYSDSTIQ EASPNFEKAY TLPVLPSEKD FNGSDASTQL NTHYAFSKLT YKSSSGHEVE NSTTDTQVIS HEKENKLESL VLTHLSRCDS DLCEMNAGMP KGNLNEQDPK HCPESEKCLL SIEDEESQQS ILSSLENHSQ QSTQPEMHKY GQLVKVELEE NAEDDKTENQ IPQRMTRNKA NTMANQSKQI LASCTLLSEK DSESSSPRGR IRLTEDDDPQ IHHPRKRKVS RVPQPVQVSP SLLQAKEKTQ QSLAAIVDSL KLDEIQPYSS ERANPYFEYL HIRKKIEEKR KLLCSVIPQA PQYYDEYVTF NGSYLLDGNP LSKICIPTIT PPPSLSDPLK ELFRQQEVVR MKLRLQHSIE REKLIVSNEQ EVLRVHYRAA RTLANQTLPF SACTVLLDAE VYNVPLDSQS DDSKTSVRDR FNARQFMSWL QDVDDKFDKL KTCLLMRQQH EAAALNAVQR LEWQLKLQEL DPATYKSISI YEIQEFYVPL VDVNDDFELT PI
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