Golgi-associated kinase 1B (GASK1B)

About Golgi-associated kinase 1B

Golgi-associated kinase 1B (GASK1B) is a protein from Homo sapiens identified by UniProt accession Q6UWH4, 519 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Golgi-associated kinase 1B
UniProt accession	Q6UWH4
Gene	GASK1B
Organism	Homo sapiens
Length	519 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.31
reticulocyte measurement · score 0.23
self reported educational attainment · score 0.18
chronotype measurement · score 0.06
pulse pressure measurement · score 0.03
blood protein measurement · score 0.03
neoplasm · score 0.03
in situ carcinoma · score 0.03
cancer · score 0.02
clear cell renal carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UWH4-F1	alphafold	PREDICTED	71.65	—

Amino-acid sequence (519 residues)

MTCPDKPGQL INWFICSLCV PRVRKLWSSR RPRTRRNLLL GTACAIYLGF LVSQVGRASL QHGQAAEKGP HRSRDTAEPS FPEIPLDGTL APPESQGNGS TLQPNVVYIT LRSKRSKPAN IRGTVKPKRR KKHAVASAAP GQEALVGPSL QPQEAAREAD AVAPGYAQGA NLVKIGERPW RLVRGPGVRA GGPDFLQPSS RESNIRIYSE SAPSWLSKDD IRRMRLLADS AVAGLRPVSS RSGARLLVLE GGAPGAVLRC GPSPCGLLKQ PLDMSEVFAF HLDRILGLNR TLPSVSRKAE FIQDGRPCPI ILWDASLSSA SNDTHSSVKL TWGTYQQLLK QKCWQNGRVP KPESGCTEIH HHEWSKMALF DFLLQIYNRL DTNCCGFRPR KEDACVQNGL RPKCDDQGSA ALAHIIQRKH DPRHLVFIDN KGFFDRSEDN LNFKLLEGIK EFPASAVSVL KSQHLRQKLL QSLFLDKVYW ESQGGRQGIE KLIDVIEHRA KILITYINAH GVKVLPMNE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards