Prostate androgen-regulated mucin-like protein 1…

About Prostate androgen-regulated mucin-like protein 1

Prostate androgen-regulated mucin-like protein 1 (PARM1) is a protein from Homo sapiens identified by UniProt accession Q6UWI2, 310 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	Prostate androgen-regulated mucin-like protein 1
UniProt accession	Q6UWI2
Gene	PARM1
Organism	Homo sapiens
Length	310 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

calcium measurement · score 0.45
nephrotic syndrome · score 0.33
adolescent idiopathic scoliosis · score 0.33
primary angle closure glaucoma · score 0.09
pulmonary arterial hypertension · score 0.07
C-X-C motif chemokine 10 measurement · score 0.03
esterified cholesterol measurement · score 0.03
low density lipoprotein cholesterol measurement · score 0.03
cancer · score 0.02
diffuse large B-cell lymphoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UWI2-F1	alphafold	PREDICTED	52.07	—

Amino-acid sequence (310 residues)

MVYKTLFALC ILTAGWRVQS LPTSAPLSVS LPTNIVPPTT IWTSSPQNTD ADTASPSNGT HNNSVLPVTA SAPTSLLPKN ISIESREEEI TSPGSNWEGT NTDPSPSGFS STSGGVHLTT TLEEHSSGTP EAGVAATLSQ SAAEPPTLIS PQAPASSPSS LSTSPPEVFS ASVTTNHSST VTSTQPTGAP TAPESPTEES SSDHTPTSHA TAEPVPQEKT PPTTVSGKVM CELIDMETTT TFPRVIMQEV EHALSSGSIA AITVTVIAVV LLVFGVAAYL KIRHSSYGRL LDDHDYGSWG NYNNPLYDDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Prostate androgen-regulated mucin-like protein 1 (PARM1)