About UDP-glucuronosyltransferase 2A3
UDP-glucuronosyltransferase 2A3 (UGT2A3) is a protein
from Homo sapiens identified by UniProt accession
Q6UWM9, 527 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | UDP-glucuronosyltransferase 2A3 |
|---|
| UniProt accession | Q6UWM9 |
|---|
| Gene | UGT2A3 |
|---|
| Organism | Homo sapiens |
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| Length | 527 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (59)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin concentration · score 0.21
- neurodegenerative disease · score 0.20
- cutaneous melanoma · score 0.18
- lung adenocarcinoma · score 0.17
- glioblastoma multiforme · score 0.17
- diverticulitis · score 0.11
- squamous cell lung carcinoma · score 0.10
- mean corpuscular hemoglobin · score 0.10
- Red cell distribution width · score 0.09
- Barrett's esophagus · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UWM9-F1 | alphafold | PREDICTED | 92.33 | — |
Amino-acid sequence (527 residues)
MRSDKSALVF LLLQLFCVGC GFCGKVLVWP CDMSHWLNVK VILEELIVRG HEVTVLTHSK PSLIDYRKPS ALKFEVVHMP QDRTEENEIF VDLALNVLPG LSTWQSVIKL NDFFVEIRGT LKMMCESFIY NQTLMKKLQE TNYDVMLIDP VIPCGDLMAE LLAVPFVLTL RISVGGNMER SCGKLPAPLS YVPVPMTGLT DRMTFLERVK NSMLSVLFHF WIQDYDYHFW EEFYSKALGR PTTLCETVGK AEIWLIRTYW DFEFPQPYQP NFEFVGGLHC KPAKALPKEM ENFVQSSGED GIVVFSLGSL FQNVTEEKAN IIASALAQIP QKVLWRYKGK KPSTLGANTR LYDWIPQNDL LGHPKTKAFI THGGMNGIYE AIYHGVPMVG VPIFGDQLDN IAHMKAKGAA VEINFKTMTS EDLLRALRTV ITDSSYKENA MRLSRIHHDQ PVKPLDRAVF WIEFVMRHKG AKHLRSAAHD LTWFQHYSID VIGFLLACVA TAIFLFTKCF LFSCQKFNKT RKIEKRE
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