Serine protease inhibitor Kazal-type 6 (SPINK6)

About Serine protease inhibitor Kazal-type 6

Serine protease inhibitor Kazal-type 6 (SPINK6) is a protein from Homo sapiens identified by UniProt accession Q6UWN8, 80 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Serine protease inhibitor Kazal-type 6
UniProt accession	Q6UWN8
Gene	SPINK6
Organism	Homo sapiens
Length	80 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.23
blood protein measurement · score 0.23
hepatocellular carcinoma · score 0.08
neoplasm · score 0.07
X-linked severe congenital neutropenia · score 0.05
neutropenia, severe congenital, 2, autosomal dominant · score 0.05
squamous cell carcinoma · score 0.05
neutropenia-monocytopenia-deafness syndrome · score 0.05
actinic keratosis · score 0.05
sebaceous of Jadassohn nevus · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UWN8-F1	alphafold	PREDICTED	87.40	—

Amino-acid sequence (80 residues)

MKLSGMFLLL SLALFCFLTG VFSQGGQVDC GEFQDPKVYC TRESNPHCGS DGQTYGNKCA FCKAIVKSGG KISLKHPGKC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards