V-set and transmembrane domain-containing protein 1…

About V-set and transmembrane domain-containing protein 1

V-set and transmembrane domain-containing protein 1 (VSTM1) is a protein from Homo sapiens identified by UniProt accession Q6UX27, 236 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	V-set and transmembrane domain-containing protein 1
UniProt accession	Q6UX27
Gene	VSTM1
Organism	Homo sapiens
Length	236 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.33
Rheumatoid arthritis · score 0.08
Systemic lupus erythematosus · score 0.06
osteosarcoma · score 0.03
Sepsis · score 0.02
acute myeloid leukemia · score 0.01
coronary artery disease · score 0.01
meningococcal infection · score 0.01
systemic juvenile idiopathic arthritis · score 0.01
infection · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UX27-F1	alphafold	PREDICTED	76.24	—

Amino-acid sequence (236 residues)

MTAEFLSLLC LGLCLGYEDE KKNEKPPKPS LHAWPSSVVE AESNVTLKCQ AHSQNVTFVL RKVNDSGYKQ EQSSAENEAE FPFTDLKPKD AGRYFCAYKT TASHEWSESS EHLQLVVTDK HDELEAPSMK TDTRTIFVAI FSCISILLLF LSVFIIYRCS QHSSSSEEST KRTSHSKLPE QEAAEADLSN MERVSLSTAD PQGVTYAELS TSALSEAASD TTQEPPGSHE YAALKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

V-set and transmembrane domain-containing protein 1 (VSTM1)