About Amelotin
Amelotin (AMTN) is a protein
from Homo sapiens identified by UniProt accession
Q6UX39, 209 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Amelotin |
|---|
| UniProt accession | Q6UX39 |
|---|
| Gene | AMTN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 209 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (117)
Diseases linked to this target (Open Targets).
- Hypocalcified amelogenesis imperfecta · score 0.47
- amelogenesis imperfecta type 3B · score 0.46
- neurodegenerative disease · score 0.27
- amelogenesis imperfecta · score 0.20
- Hypomaturation amelogenesis imperfecta · score 0.11
- Hypoplastic amelogenesis imperfecta · score 0.10
- tooth agenesis · score 0.08
- amelogenesis imperfecta hypomaturation type 2A4 · score 0.07
- dentin dysplasia type I · score 0.07
- amelogenesis imperfecta, IIa 1K · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UX39-F1 | alphafold | PREDICTED | 48.40 | — |
Amino-acid sequence (209 residues)
MRSTILLFCL LGSTRSLPQL KPALGLPPTK LAPDQGTLPN QQQSNQVFPS LSLIPLTQML TLGPDLHLLN PAAGMTPGTQ THPLTLGGLN VQQQLHPHVL PIFVTQLGAQ GTILSSEELP QIFTSLIIHS LFPGGILPTS QAGANPDVQD GSLPAGGAGV NPATQGTPAG RLPTPSGTDD DFAVTTPAGI QRSTHAIEEA TTESANGIQ
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