Butyrophilin-like protein 8 (BTNL8)

About Butyrophilin-like protein 8

Butyrophilin-like protein 8 (BTNL8) is a protein from Homo sapiens identified by UniProt accession Q6UX41, 500 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Butyrophilin-like protein 8
UniProt accession	Q6UX41
Gene	BTNL8
Organism	Homo sapiens
Length	500 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.29
cutaneous melanoma · score 0.12
Barrett's esophagus · score 0.08
Pneumothorax · score 0.06
esophageal adenocarcinoma · score 0.05
colorectal cancer · score 0.03
colorectal adenocarcinoma · score 0.03
neoplasm · score 0.03
inflammatory bowel disease · score 0.01
major depressive disorder · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UX41-F1	alphafold	PREDICTED	86.35	—

Amino-acid sequence (500 residues)

MALMLSLVLS LLKLGSGQWQ VFGPDKPVQA LVGEDAAFSC FLSPKTNAEA MEVRFFRGQF SSVVHLYRDG KDQPFMQMPQ YQGRTKLVKD SIAEGRISLR LENITVLDAG LYGCRISSQS YYQKAIWELQ VSALGSVPLI SITGYVDRDI QLLCQSSGWF PRPTAKWKGP QGQDLSTDSR TNRDMHGLFD VEISLTVQEN AGSISCSMRH AHLSREVESR VQIGDTFFEP ISWHLATKVL GILCCGLFFG IVGLKIFFSK FQWKIQAELD WRRKHGQAEL RDARKHAVEV TLDPETAHPK LCVSDLKTVT HRKAPQEVPH SEKRFTRKSV VASQSFQAGK HYWEVDGGHN KRWRVGVCRD DVDRRKEYVT LSPDHGYWVL RLNGEHLYFT LNPRFISVFP RTPPTKIGVF LDYECGTISF FNINDQSLIY TLTCRFEGLL RPYIEYPSYN EQNGTPIVIC PVTQESEKEA SWQRASAIPE TSNSESSSQA TTPFLPRGEM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards