About Protein IL-40
Protein IL-40 (C17orf99) is a protein
from Homo sapiens identified by UniProt accession
Q6UX52, 265 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Protein IL-40 |
|---|
| UniProt accession | Q6UX52 |
|---|
| Gene | C17orf99 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 265 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (45)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.32
- platelet crit · score 0.29
- body height · score 0.23
- platelet count · score 0.21
- erythrocyte count · score 0.19
- drug use measurement · score 0.16
- Rheumatoid arthritis · score 0.09
- HbA1c measurement · score 0.07
- enthesitis-related juvenile idiopathic arthritis · score 0.04
- mean corpuscular volume · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UX52-F1 | alphafold | PREDICTED | 73.60 | — |
Amino-acid sequence (265 residues)
MGLPGLFCLA VLAASSFSKA REEEITPVVS IAYKVLEVFP KGRWVLITCC APQPPPPITY SLCGTKNIKV AKKVVKTHEP ASFNLNVTLK SSPDLLTYFC WASSTSGAHV DSARLQMHWE LWSKPVSELR ANFTLQDRGA GPRVEMICQA SSGSPPITNS LIGKDGQVHL QQRPCHRQPA NFSFLPSQTS DWFWCQAANN ANVQHSALTV VPPGGDQKME DWQGPLESPI LALPLYRSTR RLSEEEFGGF RIGNGEVRGR KAAAM
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