About Plexin domain-containing protein 2
Plexin domain-containing protein 2 (PLXDC2) is a protein
from Homo sapiens identified by UniProt accession
Q6UX71, 529 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Plexin domain-containing protein 2 |
|---|
| UniProt accession | Q6UX71 |
|---|
| Gene | PLXDC2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 529 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (80)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.52
- blood protein measurement · score 0.49
- bone quantitative ultrasound measurement · score 0.49
- FEV/FVC ratio · score 0.46
- coagulation factor V measurement · score 0.44
- pulse pressure measurement · score 0.41
- cortical thickness · score 0.38
- bone density · score 0.37
- mathematical ability · score 0.37
- self reported educational attainment · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UX71-F1 | alphafold | PREDICTED | 69.59 | — |
Amino-acid sequence (529 residues)
MARFPKADLA AAGVMLLCHF FTDQFQFADG KPGDQILDWQ YGVTQAFPHT EEEVEVDSHA YSHRWKRNLD FLKAVDTNRA SVGQDSPEPR SFTDLLLDDG QDNNTQIEED TDHNYYISRI YGPSDSASRD LWVNIDQMEK DKVKIHGILS NTHRQAARVN LSFDFPFYGH FLREITVATG GFIYTGEVVH RMLTATQYIA PLMANFDPSV SRNSTVRYFD NGTALVVQWD HVHLQDNYNL GSFTFQATLL MDGRIIFGYK EIPVLVTQIS STNHPVKVGL SDAFVVVHRI QQIPNVRRRT IYEYHRVELQ MSKITNISAV EMTPLPTCLQ FNRCGPCVSS QIGFNCSWCS KLQRCSSGFD RHRQDWVDSG CPEESKEKMC ENTEPVETSS RTTTTVGATT TQFRVLTTTR RAVTSQFPTS LPTEDDTKIA LHLKDNGAST DDSAAEKKGG TLHAGLIIGI LILVLIVATA ILVTVYMYHH PTSAASIFFI ERRPSRWPAM KFRRGSGHPA YAEVEPVGEK EGFIVSEQC
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