Ly6/PLAUR domain-containing protein 8 (LYPD8)

About Ly6/PLAUR domain-containing protein 8

Ly6/PLAUR domain-containing protein 8 (LYPD8) is a protein from Homo sapiens identified by UniProt accession Q6UX82, 237 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Ly6/PLAUR domain-containing protein 8
UniProt accession	Q6UX82
Gene	LYPD8
Organism	Homo sapiens
Length	237 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

inflammatory bowel disease · score 0.07
Autosomal recessive early-onset inflammatory bowel disease · score 0.06
Hirschsprung disease · score 0.06
ulcerative colitis · score 0.05
inflammatory bowel disease 30 · score 0.05
hereditary mixed polyposis syndrome · score 0.05
Crohn's disease · score 0.05
immunodeficiency due to MASP-2 deficiency · score 0.05
annular pancreas · score 0.05
colorectal cancer, susceptibility to, 3 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UX82-F1	alphafold	PREDICTED	79.25	—

Amino-acid sequence (237 residues)

MKGILVAGIT AVLVAAVESL SCVQCNSWEK SCVNSIASEC PSHANTSCIS SSASSSLETP VRLYQNMFCS AENCSEETHI TAFTVHVSAE EHFHFVSQCC QGKECSNTSD ALDPPLKNVS SNAECPACYE SNGTSCHGKP WKCYEEEQCV FLVAELKNDI ESKSLVLKGC SNVSNATCQF LSGENKTLGG VIFRKFECAN VNSLTPTSAP TTSHNVGSKA SLYLLALASL LLRGLLP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards