About Ly6/PLAUR domain-containing protein 2
Ly6/PLAUR domain-containing protein 2 (LYPD2) is a protein
from Homo sapiens identified by UniProt accession
Q6UXB3, 125 residues long.
MolForge cross-references it against 0 known binders and
115 disease associations.
Target properties
| Protein name | Ly6/PLAUR domain-containing protein 2 |
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| UniProt accession | Q6UXB3 |
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| Gene | LYPD2 |
|---|
| Organism | Homo sapiens |
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| Length | 125 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (115)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- Blackfan-Diamond anemia · score 0.06
- X-linked severe congenital neutropenia · score 0.06
- calcium measurement · score 0.06
- thrombocytopenia 4 · score 0.05
- neutrophil immunodeficiency syndrome · score 0.05
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.05
- nonimmune chronic idiopathic neutropenia of adults · score 0.05
- X-linked sideroblastic anemia 1 · score 0.05
- thrombocytopenia 2 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UXB3-F1 | alphafold | PREDICTED | 76.06 | — |
Amino-acid sequence (125 residues)
MRGTRLALLA LVLAACGELA PALRCYVCPE PTGVSDCVTI ATCTTNETMC KTTLYSREIV YPFQGDSTVT KSCASKCKPS DVDGIGQTLP VSCCNTELCN VDGAPALNSL HCGALTLLPL LSLRL
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