About Apical endosomal glycoprotein
Apical endosomal glycoprotein (MAMDC4) is a protein
from Homo sapiens identified by UniProt accession
Q6UXC1, 1216 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | Apical endosomal glycoprotein |
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| UniProt accession | Q6UXC1 |
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| Gene | MAMDC4 |
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| Organism | Homo sapiens |
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| Length | 1216 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (18)
Diseases linked to this target (Open Targets).
- platelet component distribution width · score 0.07
- basophil count · score 0.06
- hepatocellular carcinoma · score 0.02
- PHF-tau measurement · score 0.02
- lymphocyte:monocyte ratio · score 0.02
- diabetes mellitus · score 0.01
- cancer · score 0.01
- autoimmune thrombocytopenic purpura · score 0.01
- Duane retraction syndrome · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UXC1-F1 | alphafold | PREDICTED | 79.09 | — |
Amino-acid sequence (1216 residues)
MPLSSHLLPA LVLFLAGSSG WAWVPNHCRS PGQAVCNFVC DCRDCSDEAQ CGYHGASPTL GAPFACDFEQ DPCGWRDIST SGYSWLRDRA GAALEGPGPH SDHTLGTDLG WYMAVGTHRG KEASTAALRS PTLREAASSC KLRLWYHAAS GDVAELRVEL THGAETLTLW QSTGPWGPGW QELAVTTGRI RGDFRVTFSA TRNATHRGAV ALDDLEFWDC GLPTPQANCP PGHHHCQNKV CVEPQQLCDG EDNCGDLSDE NPLTCGRHIA TDFETGLGPW NRSEGWSRNH RAGGPERPSW PRRDHSRNSA QGSFLVSVAE PGTPAILSSP EFQASGTSNC SLVFYQYLSG SEAGCLQLFL QTLGPGAPRA PVLLRRRRGE LGTAWVRDRV DIQSAYPFQI LLAGQTGPGG VVGLDDLILS DHCRPVSEVS TLQPLPPGPR APAPQPLPPS SRLQDSCKQG HLACGDLCVP PEQLCDFEEQ CAGGEDEQAC GTTDFESPEA GGWEDASVGR LQWRRVSAQE SQGSSAAAAG HFLSLQRAWG QLGAEARVLT PLLGPSGPSC ELHLAYYLQS QPRGFLALVV VDNGSRELAW QALSSSAGIW KVDKVLLGAR RRPFRLEFVG LVDLDGPDQQ GAGVDNVTLR DCSPTVTTER DREVSCNFER DTCSWYPGHL SDTHWRWVES RGPDHDHTTG QGHFVLLDPT DPLAWGHSAH LLSRPQVPAA PTECLSFWYH LHGPQIGTLR LAMRREGEET HLWSRSGTQG NRWHEAWATL SHQPGSHAQY QLLFEGLRDG YHGTMALDDV AVRPGPCWAP NYCSFEDSDC GFSPGGQGLW RRQANASGHA AWGPPTDHTT ETAQGHYMVV DTSPDALPRG QTASLTSKEH RPLAQPACLT FWYHGSLRSP GTLRVYLEER GRHQVLSLSA HGGLAWRLGS MDVQAERAWR VVFEAVAAGV AHSYVALDDL LLQDGPCPQP GSCDFESGLC GWSHLAWPGL GGYSWDWGGG ATPSRYPQPP VDHTLGTEAG HFAFFETGVL GPGGRAAWLR SEPLPATPAS CLRFWYHMGF PEHFYKGELK VLLHSAQGQL AVWGAGGHRR HQWLEAQVEV ASAKEFQIVF EATLGGQPAL GPIALDDVEY LAGQHCQQPA PSPGNTAAPG SVPAVVGSAL LLLMLLVLLG LGGRRWLQKK GSCPFQSNTE ATAPGFDNIL FNADGVTLPA SVTSDP
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