Histidine-rich carboxyl terminus protein 1 (HRCT1)

About Histidine-rich carboxyl terminus protein 1

Histidine-rich carboxyl terminus protein 1 (HRCT1) is a protein from Homo sapiens identified by UniProt accession Q6UXD1, 115 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Histidine-rich carboxyl terminus protein 1
UniProt accession	Q6UXD1
Gene	HRCT1
Organism	Homo sapiens
Length	115 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

hypertension · score 0.38
neurodegenerative disease · score 0.37
systolic blood pressure · score 0.36
diastolic blood pressure · score 0.34
cardiovascular disease · score 0.33
essential hypertension · score 0.26
blood pressure · score 0.26
BMI-adjusted hip circumference · score 0.16
body height · score 0.10
electrocardiography · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UXD1-F1	alphafold	PREDICTED	63.75	—

Amino-acid sequence (115 residues)

MLGLLGSTAL VGWITGAAVA VLLLLLLLAT CLFHGRQDCD VERNRTAAGG NRVRRAQPWP FRRRGHLGIF HHHRHPGHVS HVPNVGLHHH HHPRHTPHHL HHHHHPHRHH PRHAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards