Butyrophilin-like protein 3 (BTNL3)

About Butyrophilin-like protein 3

Butyrophilin-like protein 3 (BTNL3) is a protein from Homo sapiens identified by UniProt accession Q6UXE8, 466 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	Butyrophilin-like protein 3
UniProt accession	Q6UXE8
Gene	BTNL3
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.33
high density lipoprotein cholesterol measurement · score 0.28
apolipoprotein A 1 measurement · score 0.28
Barrett's esophagus · score 0.09
esophageal adenocarcinoma · score 0.05
neoplasm · score 0.03
colorectal adenocarcinoma · score 0.02
colorectal cancer · score 0.02
breast carcinoma · score 0.02
inflammatory bowel disease · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UXE8-F1	alphafold	PREDICTED	89.48	—

Amino-acid sequence (466 residues)

MAFVLILVLS FYELVSGQWQ VTGPGKFVQA LVGEDAVFSC SLFPETSAEA MEVRFFRNQF HAVVHLYRDG EDWESKQMPQ YRGRTEFVKD SIAGGRVSLR LKNITPSDIG LYGCWFSSQI YDEEATWELR VAALGSLPLI SIVGYVDGGI QLLCLSSGWF PQPTAKWKGP QGQDLSSDSR ANADGYSLYD VEISIIVQEN AGSILCSIHL AEQSHEVESK VLIGETFFQP SPWRLASILL GLLCGALCGV VMGMIIVFFK SKGKIQAELD WRRKHGQAEL RDARKHAVEV TLDPETAHPK LCVSDLKTVT HRKAPQEVPH SEKRFTRKSV VASQGFQAGK HYWEVDVGQN VGWYVGVCRD DVDRGKNNVT LSPNNGYWVL RLTTEHLYFT FNPHFISLPP STPPTRVGVF LDYEGGTISF FNTNDQSLIY TLLTCQFEGL LRPYIQHAMY DEEKGTPIFI CPVSWG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards