Transmembrane protein 108 (TMEM108)

About Transmembrane protein 108

Transmembrane protein 108 (TMEM108) is a protein from Homo sapiens identified by UniProt accession Q6UXF1, 575 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Transmembrane protein 108
UniProt accession	Q6UXF1
Gene	TMEM108
Organism	Homo sapiens
Length	575 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.36
age at menarche · score 0.35
urate measurement · score 0.32
bone density · score 0.32
protein measurement · score 0.31
brain measurement · score 0.27
chronotype measurement · score 0.20
cortical thickness · score 0.17
late-onset Alzheimers disease · score 0.13
daytime rest measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UXF1-F1	alphafold	PREDICTED	45.28	—

Amino-acid sequence (575 residues)

MKRSLQALYC QLLSFLLILA LTEALAFAIQ EPSPRESLQV LPSGTPPGTM VTAPHSSTRH TSVVMLTPNP DGPPSQAAAP MATPTPRAEG HPPTHTISTI AATVTAPHSE SSLSTGPAPA AMATTSSKPE GRPRGQAAPT ILLTKPPGAT SRPTTAPPRT TTRRPPRPPG SSRKGAGNSS RPVPPAPGGH SRSKEGQRGR NPSSTPLGQK RPLGKIFQIY KGNFTGSVEP EPSTLTPRTP LWGYSSSPQP QTVAATTVPS NTSWAPTTTS LGPAKDKPGL RRAAQGGGST FTSQGGTPDA TAASGAPVSP QAAPVPSQRP HHGDPQDGPS HSDSWLTVTP GTSRPLSTSS GVFTAATGPT PAAFDTSVSA PSQGIPQGAS TTPQAPTHPS RVSESTISGA KEETVATLTM TDRVPSPLST VVSTATGNFL NRLVPAGTWK PGTAGNISHV AEGDKPQHRA TICLSKMDIA WVILAISVPI SSCSVLLTVC CMKRKKKTAN PENNLSYWNN TITMDYFNRH AVELPREIQS LETSEDQLSE PRSPANGDYR DTGMVLVNPF CQETLFVGND QVSEI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards