C-type lectin domain family 18 member B (CLEC18B)

About C-type lectin domain family 18 member B

C-type lectin domain family 18 member B (CLEC18B) is a protein from Homo sapiens identified by UniProt accession Q6UXF7, 455 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	C-type lectin domain family 18 member B
UniProt accession	Q6UXF7
Gene	CLEC18B
Organism	Homo sapiens
Length	455 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.11
glioblastoma multiforme · score 0.08
diet measurement · score 0.07
leukocyte count · score 0.06
monocyte count · score 0.05
risk-taking behaviour · score 0.05
systolic blood pressure · score 0.04
mood instability measurement · score 0.04
neutrophil percentage of leukocytes · score 0.03
Down syndrome · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UXF7-F1	alphafold	PREDICTED	78.97	—

Amino-acid sequence (455 residues)

MLHPETSPGR GHLLAVLLAL LGTTWAEVWP PQLQEQAPMA GALNRKESFL LLSLHNRLRS WVQPPAADMR RLDWSDSLAQ LAQARAALCG IPTPSLASGL WRTLQVGWNM QLLPAGLASF VEVVSLWFAE GQRYSHAAGE CARNATCTHY TQLVWATSSQ LGCGRHLCSA GQTAIEAFVC AYSPGGNWEV NGKTIIPYKK GAWCSLCTAS VSGCFKAWDH AGGLCEVPRN PCRMSCQNHG RLNISTCHCH CPPGYTGRYC QVRCSLQCVH GRFREEECSC VCDIGYGGAQ CATKVHFPFH TCDLRIDGDC FMVSSEADTY YRARMKCQRK GGVLAQIKSQ KVQDILAFYL GRLETTNEVI DSDFETRNFW IGLTYKTAKD SFRWATGEHQ AFTSFAFGQP DNHGLVWLSA AMGFGNCVEL QASAAFNWND QRCKTRNRYI CQFAQEHISR WGPGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards