About Endosome/lysosome-associated apoptosis and autophagy regulator 1
Endosome/lysosome-associated apoptosis and autophagy regulator 1 (ELAPOR1) is a protein
from Homo sapiens identified by UniProt accession
Q6UXG2, 1013 residues long.
MolForge cross-references it against 0 known binders and
144 disease associations.
Target properties
| Protein name | Endosome/lysosome-associated apoptosis and autophagy regulator 1 |
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| UniProt accession | Q6UXG2 |
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| Gene | ELAPOR1 |
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| Organism | Homo sapiens |
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| Length | 1013 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (144)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.24
- alkaline phosphatase measurement · score 0.11
- azoospermia · score 0.11
- alcohol-related disorders · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 48 · score 0.07
- spermatogenic failure 20 · score 0.07
- Barrett's esophagus · score 0.07
- spermatogenic failure, X-linked, 3 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UXG2-F1 | alphafold | PREDICTED | 77.21 | — |
Amino-acid sequence (1013 residues)
MAEPGHSHHL SARVRGRTER RIPRLWRLLL WAGTAFQVTQ GTGPELHACK ESEYHYEYTA CDSTGSRWRV AVPHTPGLCT SLPDPIKGTE CSFSCNAGEF LDMKDQSCKP CAEGRYSLGT GIRFDEWDEL PHGFASLSAN MELDDSAAES TGNCTSSKWV PRGDYIASNT DECTATLMYA VNLKQSGTVN FEYYYPDSSI IFEFFVQNDQ CQPNADDSRW MKTTEKGWEF HSVELNRGNN VLYWRTTAFS VWTKVPKPVL VRNIAITGVA YTSECFPCKP GTYADKQGSS FCKLCPANSY SNKGETSCHQ CDPDKYSEKG SSSCNVRPAC TDKDYFYTHT ACDANGETQL MYKWAKPKIC SEDLEGAVKL PASGVKTHCP PCNPGFFKTN NSTCQPCPYG SYSNGSDCTR CPAGTEPAVG FEYKWWNTLP TNMETTVLSG INFEYKGMTG WEVAGDHIYT AAGASDNDFM ILTLVVPGFR PPQSVMADTE NKEVARITFV FETLCSVNCE LYFMVGVNSR TNTPVETWKG SKGKQSYTYI IEENTTTSFT WAFQRTTFHE ASRKYTNDVA KIYSINVTNV MNGVASYCRP CALEASDVGS SCTSCPAGYY IDRDSGTCHS CPTNTILKAH QPYGVQACVP CGPGTKNNKI HSLCYNDCTF SRNTPTRTFN YNFSALANTV TLAGGPSFTS KGLKYFHHFT LSLCGNQGRK MSVCTDNVTD LRIPEGESGF SKSITAYVCQ AVIIPPEVTG YKAGVSSQPV SLADRLIGVT TDMTLDGITS PAELFHLESL GIPDVIFFYR SNDVTQSCSS GRSTTIRVRC SPQKTVPGSL LLPGTCSDGT CDGCNFHFLW ESAAACPLCS VADYHAIVSS CVAGIQKTTY VWREPKLCSG GISLPEQRVT ICKTIDFWLK VGISAGTCTA ILLTVLTCYF WKKNQKLEYK YSKLVMNATL KDCDLPAADS CAIMEGEDVE DDLIFTSKKS LFGKIKSFTS KRTPDGFDSV PLKTSSGGLD MDL
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