About Leucine-rich repeat neuronal protein 1
Leucine-rich repeat neuronal protein 1 (LRRN1) is a protein
from Homo sapiens identified by UniProt accession
Q6UXK5, 716 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Leucine-rich repeat neuronal protein 1 |
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| UniProt accession | Q6UXK5 |
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| Gene | LRRN1 |
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| Organism | Homo sapiens |
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| Length | 716 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (59)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- risk-taking behaviour · score 0.32
- metabolite measurement · score 0.25
- sleep duration · score 0.18
- high density lipoprotein cholesterol measurement · score 0.18
- age at first sexual intercourse measurement · score 0.18
- mathematical ability · score 0.17
- empathy measurement · score 0.16
- lumbar disc degeneration · score 0.15
- attention deficit hyperactivity disorder · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UXK5-F1 | alphafold | PREDICTED | 81.96 | — |
Amino-acid sequence (716 residues)
MARMSFVIAA CQLVLGLLMT SLTESSIQNS ECPQLCVCEI RPWFTPQSTY REATTVDCND LRLTRIPSNL SSDTQVLLLQ SNNIAKTVDE LQQLFNLTEL DFSQNNFTNI KEVGLANLTQ LTTLHLEENQ ITEMTDYCLQ DLSNLQELYI NHNQISTISA HAFAGLKNLL RLHLNSNKLK VIDSRWFDST PNLEILMIGE NPVIGILDMN FKPLANLRSL VLAGMYLTDI PGNALVGLDS LESLSFYDNK LVKVPQLALQ KVPNLKFLDL NKNPIHKIQE GDFKNMLRLK ELGINNMGEL VSVDRYALDN LPELTKLEAT NNPKLSYIHR LAFRSVPALE SLMLNNNALN AIYQKTVESL PNLREISIHS NPLRCDCVIH WINSNKTNIR FMEPLSMFCA MPPEYKGHQV KEVLIQDSSE QCLPMISHDS FPNRLNVDIG TTVFLDCRAM AEPEPEIYWV TPIGNKITVE TLSDKYKLSS EGTLEISNIQ IEDSGRYTCV AQNVQGADTR VATIKVNGTL LDGTQVLKIY VKQTESHSIL VSWKVNSNVM TSNLKWSSAT MKIDNPHITY TARVPVDVHE YNLTHLQPST DYEVCLTVSN IHQQTQKSCV NVTTKNAAFA VDISDQETST ALAAVMGSMF AVISLASIAV YFAKRFKRKN YHHSLKKYMQ KTSSIPLNEL YPPLINLWEG DSEKDKDGSA DTKPTQVDTS RSYYMW
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