About Leucine-rich repeats and immunoglobulin-like domains protein 3
Leucine-rich repeats and immunoglobulin-like domains protein 3 (LRIG3) is a protein
from Homo sapiens identified by UniProt accession
Q6UXM1, 1119 residues long.
MolForge cross-references it against 0 known binders and
212 disease associations.
Target properties
| Protein name | Leucine-rich repeats and immunoglobulin-like domains protein 3 |
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| UniProt accession | Q6UXM1 |
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| Gene | LRIG3 |
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| Organism | Homo sapiens |
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| Length | 1119 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (212)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.41
- non-small cell lung carcinoma · score 0.37
- lung adenocarcinoma · score 0.37
- acinar lung adenocarcinoma · score 0.37
- bile duct carcinoma · score 0.37
- lymphoid neoplasm · score 0.37
- carcinoma of liver and intrahepatic biliary tract · score 0.37
- refractive error measurement · score 0.34
- osteoarthritis · score 0.32
- total hip arthroplasty · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UXM1-F1 | alphafold | PREDICTED | 72.97 | — |
Amino-acid sequence (1119 residues)
MSAPSLRARA AGLGLLLCAV LGRAGRSDSG GRGELGQPSG VAAERPCPTT CRCLGDLLDC SRKRLARLPE PLPSWVARLD LSHNRLSFIK ASSMSHLQSL REVKLNNNEL ETIPNLGPVS ANITLLSLAG NRIVEILPEH LKEFQSLETL DLSSNNISEL QTAFPALQLK YLYLNSNRVT SMEPGYFDNL ANTLLVLKLN RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA LKSLKMQRNG VTKLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIN RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNTL HIGNNRVSYI ADCAFRGLSS LKTLDLKNNE ISWTIEDMNG AFSGLDKLRR LILQGNRIRS ITKKAFTGLD ALEHLDLSDN AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG RSIFAVSPDG FVCDDFPKPQ ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL LHDAEMENYA HLRAQGGEVM EYTTILRLRE VEFASEGKYQ CVISNHFGSS YSVKAKLTVN MLPSFTKTPM DLTIRAGAMA RLECAAVGHP APQIAWQKDG GTDFPAARER RMHVMPEDDV FFIVDVKIED IGVYSCTAQN SAGSISANAT LTVLETPSFL RPLLDRTVTK GETAVLQCIA GGSPPPKLNW TKDDSPLVVT ERHFFAAGNQ LLIIVDSDVS DAGKYTCEMS NTLGTERGNV RLSVIPTPTC DSPQMTAPSL DDDGWATVGV VIIAVVCCVV GTSLVWVVII YHTRRRNEDC SITNTDETNL PADIPSYLSS QGTLADRQDG YVSSESGSHH QFVTSSGAGF FLPQHDSSGT CHIDNSSEAD VEAATDLFLC PFLGSTGPMY LKGNVYGSDP FETYHTGCSP DPRTVLMDHY EPSYIKKKEC YPCSHPSEES CERSFSNISW PSHVRKLLNT SYSHNEGPGM KNLCLNKSSL DFSANPEPAS VASSNSFMGT FGKALRRPHL DAYSSFGQPS DCQPRAFYLK AHSSPDLDSG SEEDGKERTD FQEENHICTF KQTLENYRTP NFQSYDLDT
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