Inactive caspase-12 (CASP12)

About Inactive caspase-12

Inactive caspase-12 (CASP12) is a protein from Homo sapiens identified by UniProt accession Q6UXS9, 341 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.

Target properties

Protein name	Inactive caspase-12
UniProt accession	Q6UXS9
Gene	CASP12
Organism	Homo sapiens
Length	341 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (199)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
cirrhosis of liver · score 0.09
acute myocardial infarction · score 0.08
non-alcoholic steatohepatitis · score 0.07
chronic hepatitis C virus infection · score 0.07
calf circumference measurement · score 0.06
oral squamous cell carcinoma · score 0.05
immunodeficiency 35 · score 0.04
diabetes mellitus · score 0.04
hyper-IgE recurrent infection syndrome 5, autosomal recessive · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UXS9-F1	alphafold	PREDICTED	76.22	—

Amino-acid sequence (341 residues)

MADEKPSNGV LVHMVKLLIK TFLDGIFDDL MENNVLNTDE IHLIGKCLKF VVSNAENLVD DITETAQIAG KIFREHLWNS KKQLSSDISS DGEREANMPG LNIRNKEFNY LHNRNGSELD LLGMRDLLEN LGYSVVIKEN LTAQEMETAL RQFAAHPEHQ SSDSTFLVFM SHSILNGICG TKHWDQEPDV LHDDTIFEIF NNRNCQSLKD KPKVIIMQAC RGNGAGIVWF TTDSGKASAD THGRLLQGNI CNDAVTKAHV EKDFIAFKSS TPHNVSWRHE TNGSVFISQI IYYFREYSWS HHLEEIFQKV QHSFETPNIL TQLPTIERLS MTRYFYLFPG N

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards