ALK and LTK ligand 1 (ALKAL1)

About ALK and LTK ligand 1

ALK and LTK ligand 1 (ALKAL1) is a protein from Homo sapiens identified by UniProt accession Q6UXT8, 129 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	ALK and LTK ligand 1
UniProt accession	Q6UXT8
Gene	ALKAL1
Organism	Homo sapiens
Length	129 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

liver amyloid deposition measurement · score 0.28
AL amyloidosis · score 0.28
neoplasm · score 0.04
colorectal adenocarcinoma · score 0.03
chronotype measurement · score 0.03
visual perception measurement · score 0.02
motion sickness · score 0.02
IGF-1 measurement · score 0.02
nonpapillary renal cell carcinoma · score 0.02
hepatocellular carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UXT8-F1	alphafold	PREDICTED	67.25	—

Amino-acid sequence (129 residues)

MRPLKPGAPL PALFLLALAL SPHGAHGRPR GRRGARVTDK EPKPLLFLPA AGAGRTPSGS RSAEIFPRDS NLKDKFIKHF TGPVTFSPEC SKHFHRLYYN TRECSTPAYY KRCARLLTRL AVSPLCSQT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards