GDNF family receptor alpha-like (GFRAL)

About GDNF family receptor alpha-like

GDNF family receptor alpha-like (GFRAL) is a protein from Homo sapiens identified by UniProt accession Q6UXV0, 394 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	GDNF family receptor alpha-like
UniProt accession	Q6UXV0
Gene	GFRAL
Organism	Homo sapiens
Length	394 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.48
blood protein measurement · score 0.43
chronotype measurement · score 0.41
body mass index · score 0.40
arterial stiffness measurement · score 0.30
daytime rest measurement · score 0.19
high density lipoprotein cholesterol measurement · score 0.16
nausea and vomiting of pregnancy severity measurement · score 0.13
circadian rhythm · score 0.07
excessive daytime sleepiness measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UXV0-F1	alphafold	PREDICTED	76.83	—

Amino-acid sequence (394 residues)

MIVFIFLAMG LSLENEYTSQ TNNCTYLREQ CLRDANGCKH AWRVMEDACN DSDPGDPCKM RNSSYCNLSI QYLVESNFQF KECLCTDDFY CTVNKLLGKK CINKSDNVKE DKFKWNLTTR SHHGFKGMWS CLEVAEACVG DVVCNAQLAS YLKACSANGN PCDLKQCQAA IRFFYQNIPF NIAQMLAFCD CAQSDIPCQQ SKEALHSKTC AVNMVPPPTC LSVIRSCQND ELCRRHYRTF QSKCWQRVTR KCHEDENCIS TLSKQDLTCS GSDDCKAAYI DILGTVLQVQ CTCRTITQSE ESLCKIFQHM LHRKSCFNYP TLSNVKGMAL YTRKHANKIT LTGFHSPFNG EVIYAAMCMT VTCGILLLVM VKLRTSRISS KARDPSSIQI PGEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards