About Izumo sperm-egg fusion protein 2
Izumo sperm-egg fusion protein 2 (IZUMO2) is a protein
from Homo sapiens identified by UniProt accession
Q6UXV1, 221 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Izumo sperm-egg fusion protein 2 |
|---|
| UniProt accession | Q6UXV1 |
|---|
| Gene | IZUMO2 |
|---|
| Organism | Homo sapiens |
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| Length | 221 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (95)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.23
- cutaneous melanoma · score 0.23
- head and neck squamous cell carcinoma · score 0.13
- genetic disorder · score 0.12
- hypertrophic cardiomyopathy · score 0.08
- Brugada syndrome · score 0.08
- Arrhythmogenic right ventricular dysplasia · score 0.08
- Romano-Ward syndrome · score 0.07
- Familial short QT syndrome · score 0.07
- familial atrial fibrillation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UXV1-F1 | alphafold | PREDICTED | 86.63 | — |
Amino-acid sequence (221 residues)
MPLALTLLLL SGLGAPGGWG CLQCDPLVLE ALGHLRSALI PSRFQLEQLQ ARAGAVLMGM EGPFFRDYAL NVFVGKVETN QLDLVASFVK NQTQHLMGNS LKDEPLLEEL VTLRANVIKE FKKVLISYEL KACNPKLCRL LKEEVLDCLH CQRITPKCIH KKYCFVDRQP RVALQYQMDS KYPRNQALLG ILISVSLAVF VFVVIVVSAC TYRQNRKLLL Q
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