About MICOS complex subunit MIC27
MICOS complex subunit MIC27 (APOOL) is a protein
from Homo sapiens identified by UniProt accession
Q6UXV4, 268 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | MICOS complex subunit MIC27 |
|---|
| UniProt accession | Q6UXV4 |
|---|
| Gene | APOOL |
|---|
| Organism | Homo sapiens |
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| Length | 268 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (13)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.25
- Acute hepatic failure · score 0.01
- neoplasm · score 0.01
- breast cancer · score 0.01
- infection · score 0.01
- infect · score 0.01
- lung carcinoma · score 0.01
- pancreatic ductal adenocarcinoma · score 0.00
- Mitochondrial myopathy · score 0.00
- esophageal carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6UXV4-F1 | alphafold | PREDICTED | 70.77 | — |
Amino-acid sequence (268 residues)
MAAIRMGKLT TMPAGLIYAS VSVHAAKQEE SKKQLVKPEQ LPIYTAPPLQ SKYVEEQPGH LQMGFASIRT ATGCYIGWCK GVYVFVKNGI MDTVQFGKDA YVYLKNPPRD FLPKMGVITV SGLAGLVSAR KGSKFKKITY PLGLATLGAT VCYPVQSVII AKVTAKKVYA TSQQIFGAVK SLWTKSSKEE SLPKPKEKTK LGSSSEIEVP AKTTHVLKHS VPLPTELSSE AKTKSESTSG ATQFMPDPKL MDHGQSHPED IDMYSTRS
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