Forkhead box protein D4-like 3 (FOXD4L3)

About Forkhead box protein D4-like 3

Forkhead box protein D4-like 3 (FOXD4L3) is a protein from Homo sapiens identified by UniProt accession Q6VB84, 417 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.

Target properties

Protein name	Forkhead box protein D4-like 3
UniProt accession	Q6VB84
Gene	FOXD4L3
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (7)

Diseases linked to this target (Open Targets).

Isolated anophthalmia - microphthalmia · score 0.05
Microphthalmia - ankyloblepharon - intellectual disability · score 0.05
nanophthalmia · score 0.04
nanophthalmos 2 · score 0.04
microphthalmia · score 0.04
adolescent idiopathic scoliosis · score 0.02
Kabuki syndrome · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6VB84-F1	alphafold	PREDICTED	56.19	—

Amino-acid sequence (417 residues)

MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PRPGPLLGAP APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRICPRPRG ATATCSSDHQ ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL PPRARCWAGT CRPRRPC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards