E3 ubiquitin-protein ligase NHLRC1 (NHLRC1)

About E3 ubiquitin-protein ligase NHLRC1

E3 ubiquitin-protein ligase NHLRC1 (NHLRC1) is a protein from Homo sapiens identified by UniProt accession Q6VVB1, 395 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase NHLRC1
UniProt accession	Q6VVB1
Gene	NHLRC1
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (135)

Diseases linked to this target (Open Targets).

Lafora disease · score 0.78
myoclonic epilepsy of Lafora 2 · score 0.75
genetic disorder · score 0.47
myoclonic epilepsy of Lafora 1 · score 0.40
disorder of glycogen metabolism · score 0.37
thiopurine metabolite measurement · score 0.35
thiopurine methyltransferase activity measurement · score 0.33
myelosuppression · score 0.31
Seizure · score 0.11
endometrial cancer · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6VVB1-F1	alphafold	PREDICTED	85.42	—

Amino-acid sequence (395 residues)

MAAEASESGP ALHELMREAE ISLLECKVCF EKFGHRQQRR PRNLSCGHVV CLACVAALAH PRTLALECPF CRRACRGCDT SDCLPVLHLI ELLGSALRQS PAAHRAAPSA PGALTCHHTF GGWGTLVNPT GLALCPKTGR VVVVHDGRRR VKIFDSGGGC AHQFGEKGDA AQDIRYPVDV TITNDCHVVV TDAGDRSIKV FDFFGQIKLV IGGQFSLPWG VETTPQNGIV VTDAEAGSLH LLDVDFAEGV LRRTERLQAH LCNPRGVAVS WLTGAIAVLE HPLALGTGVC STRVKVFSSS MQLVGQVDTF GLSLYFPSKI TASAVTFDHQ GNVIVADTSG PAILCLGKPE EFPVPKPMVT HGLSHPVALT FTKENSLLVL DTASHSIKVY KVDWG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards