About Immunoglobulin superfamily member 10
Immunoglobulin superfamily member 10 (IGSF10) is a protein
from Homo sapiens identified by UniProt accession
Q6WRI0, 2623 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Immunoglobulin superfamily member 10 |
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| UniProt accession | Q6WRI0 |
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| Gene | IGSF10 |
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| Organism | Homo sapiens |
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| Length | 2623 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (65)
Diseases linked to this target (Open Targets).
- hypogonadotropic hypogonadism · score 0.19
- Delayed puberty · score 0.19
- Hypogonadotropic hypogonadism · score 0.18
- metabolite measurement · score 0.18
- primary ovarian insufficiency · score 0.17
- genetic disorder · score 0.15
- Nizon-Isidor syndrome · score 0.12
- Cataract - intellectual disability - hypogonadism · score 0.12
- lung adenocarcinoma · score 0.09
- neoplasm · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6WRI0-F1 | alphafold | PREDICTED | 58.41 | — |
Amino-acid sequence (2623 residues)
MKVKGRGITC LLVSFAVICL VATPGGKACP RRCACYMPTE VHCTFRYLTS IPDSIPPNVE RINLGYNSLV RLMETDFSGL TKLELLMLHS NGIHTIPDKT FSDLQALQVL KMSYNKVRKL QKDTFYGLRS LTRLHMDHNN IEFINPEVFY GLNFLRLVHL EGNQLTKLHP DTFVSLSYLQ IFKISFIKFL YLSDNFLTSL PQEMVSYMPD LDSLYLHGNP WTCDCHLKWL SDWIQEKPDV IKCKKDRSPS SAQQCPLCMN PRTSKGKPLA MVSAAAFQCA KPTIDSSLKS KSLTILEDSS SAFISPQGFM APFGSLTLNM TDQSGNEANM VCSIQKPSRT SPIAFTEEND YIVLNTSFST FLVCNIDYGH IQPVWQILAL YSDSPLILER SHLLSETPQL YYKYKQVAPK PEDIFTNIEA DLRADPSWLM QDQISLQLNR TATTFSTLQI QYSSDAQITL PRAEMRPVKH KWTMISRDNN TKLEHTVLVG GTVGLNCPGQ GDPTPHVDWL LADGSKVRAP YVSEDGRILI DKSGKLELQM ADSFDTGVYH CISSNYDDAD ILTYRITVVE PLVEAYQENG IHHTVFIGET LDLPCHSTGI PDASISWVIP GNNVLYQSSR DKKVLNNGTL RILQVTPKDQ GYYRCVAANP SGVDFLIFQV SVKMKGQRPL EHDGETEGSG LDESNPIAHL KEPPGAQLRT SALMEAEVGK HTSSTSKRHN YRELTLQRRG DSTHRRFREN RRHFPPSARR IDPQHWAALL EKAKKNAMPD KRENTTVSPP PVVTQLPNIP GEEDDSSGML ALHEEFMVPA TKALNLPART VTADSRTISD SPMTNINYGT EFSPVVNSQI LPPEEPTDFK LSTAIKTTAM SKNINPTMSS QIQGTTNQHS STVFPLLLGA TEFQDSDQMG RGREHFQSRP PITVRTMIKD VNVKMLSSTT NKLLLESVNT TNSHQTSVRE VSEPRHNHFY SHTTQILSTS TFPSDPHTAA HSQFPIPRNS TVNIPLFRRF GRQRKIGGRG RIISPYRTPV LRRHRYSIFR STTRGSSEKS TTAFSATVLN VTCLSCLPRE RLTTATAALS FPSAAPITFP KADIARVPSE ESTTLVQNPL LLLENKPSVE KTTPTIKYFR TEISQVTPTG AVMTYAPTSI PMEKTHKVNA SYPRVSSTNE AKRDSVITSS LSGAITKPPM TIIAITRFSR RKIPWQQNFV NNHNPKGRLR NQHKVSLQKS TAVMLPKTSP ALPRDKVSPF HFTTLSTSVM QIPSNTLTTA HHTTTKTHNP GSLPTKKELP FPPLNPMLPS IISKDSSTKS IISTQTAIPA TTPTFPASVI TYETQTERSR AQTIQREQEP QKKNRTDPNI SPDQSSGFTT PTAMTPPVLT TAETSVKPSV SAFTHSPPEN TTGISSTISF HSRTLNLTDV IEELAQASTQ TLKSTIASET TLSSKSHQST TTRKAIIRHS TIPPFLSSSA TLMPVPISPP FTQRAVTDNV ATPISGLMTN TVVKLHESSR HNAKPQQLVA EVATSPKVHP NAKFTIGTTH FIYSNLLHST PMPALTTVKS QNSKLTPSPW AENQFWHKPY SEIAEKGKKP EVSMLATTGL SEATTLVSDW DGQKNTKKSD FDKKPVQEAT TSKLLPFDSL SRYIFEKPRI VGGKAASFTI PANSDAFLPC EAVGNPLPTI HWTRVPSGLD LSKRKQNSRV QVLPNGTLSI QRVEIQDRGQ YLCSASNLFG TDHLHVTLSV VSYPPRILER RTKEITVHSG STVELKCRAE GRPSPTVTWI LANQTVVSES SQGSRQAVVT VDGTLVLHNL SIYDRGFYKC VASNPGGQDS LLVKIQVIAA PPVILEQRRQ VIVGTWGESL KLPCTAKGTP QPSVYWVLSD GTEVKPLQFT NSKLFLFSNG TLYIRNLASS DRGTYECIAT SSTGSERRVV MLTMEERVTS PRIEAASQKR TEVNFGDKLL LNCSATGEPK PQIMWRLPSK AVVDQQHRVG SWIHVYPNGS LFIGSVTEKD SGVYLCVARN KMGDDLILMH VSLRLKPAKI DHKQYFRKQV LHGKDFQVDC KASGSPVPEI SWSLPDGTMI NNAMQADDSG HRTRRYTLFN NGTLYFNKVG VAEEGDYTCY AQNTLGKDEM KVHLTVITAA PRIRQSNKTN KRIKAGDTAV LDCEVTGDPK PKIFWLLPSN DMISFSIDRY TFHANGSLTI NKVKLLDSGE YVCVARNPSG DDTKMYKLDV VSKPPLINGL YTNRTVIKAT AVRHSKKHFD CRAEGTPSPE VMWIMPDNIF LTAPYYGSRI TVHKNGTLEI RNVRLSDSAD FICVARNEGG ESVLVVQLEV LEMLRRPTFR NPFNEKIVAQ LGKSTALNCS VDGNPPPEII WILPNGTRFS NGPQSYQYLI ASNGSFIISK TTREDAGKYR CAARNKVGYI EKLVILEIGQ KPVILTYAPG TVKGISGESL SLHCVSDGIP KPNIKWTMPS GYVVDRPQIN GKYILHDNGT LVIKEATAYD RGNYICKAQN SVGHTLITVP VMIVAYPPRI TNRPPRSIVT RTGAAFQLHC VALGVPKPEI TWEMPDHSLL STASKERTHG SEQLHLQGTL VIQNPQTSDS GIYKCTAKNP LGSDYAATYI QVI
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