About Protein zyg-11 homolog A
Protein zyg-11 homolog A (ZYG11A) is a protein
from Homo sapiens identified by UniProt accession
Q6WRX3, 759 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Protein zyg-11 homolog A |
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| UniProt accession | Q6WRX3 |
|---|
| Gene | ZYG11A |
|---|
| Organism | Homo sapiens |
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| Length | 759 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.38
- hemoglobin measurement · score 0.35
- hematocrit · score 0.35
- monocyte count · score 0.32
- mean reticulocyte volume · score 0.31
- mean corpuscular hemoglobin concentration · score 0.27
- red blood cell density measurement · score 0.27
- erythrocyte count · score 0.26
- HbA1c measurement · score 0.20
- hemoglobin A1 measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6WRX3-F1 | alphafold | PREDICTED | 90.63 | — |
Amino-acid sequence (759 residues)
MVHFLHPGHT PRNIVPPDAQ KDALGCCVVQ EEASPYTLVN ICLNVLIANL EKLCSERPDG TLCLPEHWSF PQEVAERFLR VMTWQGKLTD RTASIFRGNQ MKLKLVNIQK AKISTAAFIK AFCRHKLIEL NATAVHADLP VPDIISGLCS NRWIQQNLQC LLLDSTSIPQ NSRLLFFSQL TGLRILSVFN VCFHTEDLAN VSQLPRLESL DISNTLVTDI SALLTCKDRL KSLTMHYLKC LAMTKSQILA VIRELKCLLH LDISDHRQLK SDLAFHLLQQ KDILPNVVSL DISGGNCITD EAVELFIRLR PAMQFVGLLA TDAGSSDFFT TKQGLRVAGG ASMSQISEAL SRYRNRSCFV KEALHRLFTE TFSMEVTMPA ILKLVAIGMR NHPLDLRVQF TASACALNLT RQGLAKGMPV RLLSEVTCLL FKALKNFPHY QQLQKNCLLS LTNSRILVDV PFDRFDAAKF VMRWLCKHEN PKMQTMAVSV TSILALQLSP EQTAQLEELF MAVKELLAIV KQKTTENLDD VTFLFTLKAL WNLTDGSPAA CKHFIENQGL QIFIQVLETF SESAIQSKVL GLLNNIAEVR ELSSKLVTED VLKHINSLLC SREMEVSYFA AGIIAHLTSD RQLWISRDFQ RRTLLQDLHA TIQNWPSSSC KMTALVTYRS FKTFFPLLGN FSQPEVQLWA LWAMYHVCSK NPSKYCKMLV EEEGLQLLCD IQEHSEATPK AQQIAASILD DFRMHFMNYQ RPTLCQMPF
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