Zona pellucida-binding protein 2 (ZPBP2)

About Zona pellucida-binding protein 2

Zona pellucida-binding protein 2 (ZPBP2) is a protein from Homo sapiens identified by UniProt accession Q6X784, 338 residues long. MolForge cross-references it against 0 known binders and 148 disease associations.

Target properties

Protein name	Zona pellucida-binding protein 2
UniProt accession	Q6X784
Gene	ZPBP2
Organism	Homo sapiens
Length	338 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (148)

Diseases linked to this target (Open Targets).

asthma · score 0.36
childhood onset asthma · score 0.32
ulcerative colitis · score 0.31
lymphocyte count · score 0.30
Crohn's disease · score 0.29
rheumatoid arthritis · score 0.28
inflammatory bowel disease · score 0.27
eosinophil count · score 0.25
primary biliary cirrhosis · score 0.24
allergic rhinitis · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6X784-F1	alphafold	PREDICTED	86.85	—

Amino-acid sequence (338 residues)

MMRTCVLLSA VLWCLTGVQC PRFTLFNKKG FIYGKTGQPD KIYVELHQNS PVLICMDFKL SKKEIVDPTY LWIGPNEKTL TGNNRINITE TGQLMVKDFL EPLSGLYTCT LSYKTVKAET QEEKTVKKRY DFMVFAYREP DYSYQMAVRF TTRSCIGRYN DVFFRVLKKI LDSLISDLSC HVIEPSYKCH SVEIPEHGLI HELFIAFQVN PFAPGWKGAC NGSVDCEDTT NHNILQARDR IEDFFRSQAY IFYHNFNKTL PAMHFVDHSL QVVRLDSCRP GFGKNERLHS NCASCCVVCS PATFSPDVNV TCQTCVSVLT YGAKSCPQTS NKNQQYED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards