About Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (TPTE2) is a protein
from Homo sapiens identified by UniProt accession
Q6XPS3, 522 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 |
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| UniProt accession | Q6XPS3 |
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| Gene | TPTE2 |
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| Organism | Homo sapiens |
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| Length | 522 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (96)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.24
- breast adenocarcinoma · score 0.23
- cutaneous melanoma · score 0.18
- lung adenocarcinoma · score 0.18
- PHF-tau measurement · score 0.14
- squamous cell lung carcinoma · score 0.12
- body fat percentage · score 0.11
- head and neck squamous cell carcinoma · score 0.11
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6XPS3-F1 | alphafold | PREDICTED | 84.55 | — |
Amino-acid sequence (522 residues)
MNESPQTNEF KGTTEEAPAK ESPHTSEFKG AALVSPISKS MLERLSKFEV EDAENVASYD SKIKKIVHSI VSSFAFGIFG VFLVLLDVTL LLADLIFTDS KLYIPLEYRS ISLAIGLFFL MDVLLRVFVE GRQQYFSDLF NILDTAIIVI PLLVDVIYIF FDIKLLRNIP RWTHLVRLLR LIILIRIFHL LHQKRQLEKL MRRLVSENKR RYTRDGFDLD LTYVTERIIA MSFPSSGRQS FYRNPIEEVV RFLDKKHRNH YRVYNLCSER AYDPKHFHNR VSRIMIDDHN VPTLHEMVVF TKEVNEWMAQ DLENIVAIHC KGGKGRTGTM VCALLIASEI FLTAEESLYY FGERRTNKTH SNKFQGVETP SQNRYVGYFA QVKHLYNWNL PPRRILFIKR FIIYSIRGDV CDLKVQVVME KKVVFSSTSL GNCSILHDIE TDKILINVYD GPPLYDDVKV QFFSSNLPKY YDNCPFFFWF NTSFIQNNRL CLPRNELDNP HKQKAWKIYP PEFAVEILFG EK
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