About Dual serine/threonine and tyrosine protein kinase
Dual serine/threonine and tyrosine protein kinase (DSTYK) is a protein
from Homo sapiens identified by UniProt accession
Q6XUX3, 929 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Dual serine/threonine and tyrosine protein kinase |
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| UniProt accession | Q6XUX3 |
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| Gene | DSTYK |
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| Organism | Homo sapiens |
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| Length | 929 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (95)
Diseases linked to this target (Open Targets).
- congenital anomalies of kidney and urinary tract 1 · score 0.75
- hereditary spastic paraplegia 23 · score 0.62
- Autosomal recessive spastic paraplegia type 23 · score 0.62
- Genetic renal or urinary tract malformation · score 0.61
- neurodegenerative disease · score 0.50
- Parkinson disease · score 0.46
- lysosomal storage disease · score 0.46
- Alzheimer disease · score 0.46
- vesicoureteral reflux · score 0.46
- multiple sclerosis · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6XUX3-F1 | alphafold | PREDICTED | 80.19 | — |
Amino-acid sequence (929 residues)
MEGDGVPWGS EPVSGPGPGG GGMIRELCRG FGRYRRYLGR LRQNLRETQK FFRDIKCSHN HTCLSSLTGG GGAERGPAGD VAETGLQAGQ LSCISFPPKE EKYLQQIVDC LPCILILGQD CNVKCQLLNL LLGVQVLPTT KLGSEESCKL RRLRFTYGTQ TRVSLALPGQ YELVHTLVAH QGNWETIPEE DLEVQENNED AAHVLAELEV TMHHALLQEV DVVVAPCQGL RPTVDVLGDL VNDFLPVITY ALHKDELSER DEQELQEIRK YFSFPVFFFK VPKLGSEIID SSTRRMESER SPLYRQLIDL GYLSSSHWNC GAPGQDTKAQ SMLVEQSEKL RHLSTFSHQV LQTRLVDAAK ALNLVHCHCL DIFINQAFDM QRDLQITPKR LEYTRKKENE LYESLMNIAN RKQEEMKDMI VETLNTMKEE LLDDATNMEF KDVIVPENGE PVGTREIKCC IRQIQELIIS RLNQAVANKL ISSVDYLRES FVGTLERCLQ SLEKSQDVSV HITSNYLKQI LNAAYHVEVT FHSGSSVTRM LWEQIKQIIQ RITWVSPPAI TLEWKRKVAQ EAIESLSASK LAKSICSQFR TRLNSSHEAF AASLRQLEAG HSGRLEKTED LWLRVRKDHA PRLARLSLES CSLQDVLLHR KPKLGQELGR GQYGVVYLCD NWGGHFPCAL KSVVPPDEKH WNDLALEFHY MRSLPKHERL VDLHGSVIDY NYGGGSSIAV LLIMERLHRD LYTGLKAGLT LETRLQIALD VVEGIRFLHS QGLVHRDIKL KNVLLDKQNR AKITDLGFCK PEAMMSGSIV GTPIHMAPEL FTGKYDNSVD VYAFGILFWY ICSGSVKLPE AFERCASKDH LWNNVRRGAR PERLPVFDEE CWQLMEACWD GDPLKRPLLG IVQPMLQGIM NRLCKSNSEQ PNRGLDDST
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