Beta-1,3-glucosyltransferase (B3GLCT)

About Beta-1,3-glucosyltransferase

Beta-1,3-glucosyltransferase (B3GLCT) is a protein from Homo sapiens identified by UniProt accession Q6Y288, 498 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.

Target properties

Protein name	Beta-1,3-glucosyltransferase
UniProt accession	Q6Y288
Gene	B3GLCT
Organism	Homo sapiens
Length	498 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (149)

Diseases linked to this target (Open Targets).

Peters plus syndrome · score 0.81
genetic disorder · score 0.45
self reported educational attainment · score 0.42
blood protein measurement · score 0.38
heel bone mineral density · score 0.37
Orofacial cleft · score 0.37
mathematical ability · score 0.36
age-related macular degeneration · score 0.36
unipolar depression · score 0.33
gastroesophageal reflux disease · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6Y288-F1	alphafold	PREDICTED	86.71	—

Amino-acid sequence (498 residues)

MRPPACWWLL APPALLALLT CSLAFGLASE DTKKEVKQSQ DLEKSGISRK NDIDLKGIVF VIQSQSNSFH AKRAEQLKKS ILKQAADLTQ ELPSVLLLHQ LAKQEGAWTI LPLLPHFSVT YSRNSSWIFF CEEETRIQIP KLLETLRRYD PSKEWFLGKA LHDEEATIIH HYAFSENPTV FKYPDFAAGW ALSIPLVNKL TKRLKSESLK SDFTIDLKHE IALYIWDKGG GPPLTPVPEF CTNDVDFYCA TTFHSFLPLC RKPVKKKDIF VAVKTCKKFH GDRIPIVKQT WESQASLIEY YSDYTENSIP TVDLGIPNTD RGHCGKTFAI LERFLNRSQD KTAWLVIVDD DTLISISRLQ HLLSCYDSGE PVFLGERYGY GLGTGGYSYI TGGGGMVFSR EAVRRLLASK CRCYSNDAPD DMVLGMCFSG LGIPVTHSPL FHQARPVDYP KDYLSHQVPI SFHKHWNIDP VKVYFTWLAP SDEDKARQET QKGFREEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards