Hydroxysteroid dehydrogenase-like protein 2 (HSDL2)

About Hydroxysteroid dehydrogenase-like protein 2

Hydroxysteroid dehydrogenase-like protein 2 (HSDL2) is a protein from Homo sapiens identified by UniProt accession Q6YN16, 418 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.

Target properties

Protein name	Hydroxysteroid dehydrogenase-like protein 2
UniProt accession	Q6YN16
Gene	HSDL2
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (110)

Diseases linked to this target (Open Targets).

body height · score 0.34
hip bone size · score 0.29
hip bone mineral density · score 0.29
chronotype measurement · score 0.25
cholangiocarcinoma · score 0.10
azoospermia · score 0.09
papillary thyroid carcinoma · score 0.08
calf circumference measurement · score 0.08
melanoma · score 0.07
pachyonychia congenita · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6YN16-F1	alphafold	PREDICTED	90.10	—

Amino-acid sequence (418 residues)

MLPNTGRLAG CTVFITGASR GIGKAIALKA AKDGANIVIA AKTAQPHPKL LGTIYTAAEE IEAVGGKALP CIVDVRDEQQ ISAAVEKAIK KFGGIDILVN NASAISLTNT LDTPTKRLDL MMNVNTRGTY LASKACIPYL KKSKVAHILN ISPPLNLNPV WFKQHCAYTI AKYGMSMYVL GMAEEFKGEI AVNALWPKTA IHTAAMDMLG GPGIESQCRK VDIIADAAYS IFQKPKSFTG NFVIDENILK EEGIENFDVY AIKPGHPLQP DFFLDEYPEA VSKKVESTGA VPEFKEEKLQ LQPKPRSGAV EETFRIVKDS LSDDVVKATQ AIYLFELSGE DGGTWFLDLK SKGGNVGYGE PSDQADVVMS MTTDDFVKMF SGKLKPTMAF MSGKLKIKGN MALAIKLEKL MNQMNARL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards