Kynurenine--oxoglutarate transaminase 3 (KYAT3)

About Kynurenine--oxoglutarate transaminase 3

Kynurenine--oxoglutarate transaminase 3 (KYAT3) is a protein from Homo sapiens identified by UniProt accession Q6YP21, 454 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Kynurenine--oxoglutarate transaminase 3
UniProt accession	Q6YP21
Gene	KYAT3
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

serum metabolite measurement · score 0.18
urinary metabolite measurement · score 0.16
blood urea nitrogen measurement · score 0.13
pulse pressure measurement · score 0.10
breast cancer · score 0.07
systolic blood pressure · score 0.07
platelet crit · score 0.07
appendicular lean mass · score 0.06
creatinine measurement · score 0.05
diastolic blood pressure · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6YP21-F1	alphafold	PREDICTED	91.31	—

Amino-acid sequence (454 residues)

MFLAQRSLCS LSGRAKFLKT ISSSKILGFS TSAKMSLKFT NAKRIEGLDS NVWIEFTKLA ADPSVVNLGQ GFPDISPPTY VKEELSKIAA IDSLNQYTRG FGHPSLVKAL SYLYEKLYQK QIDSNKEILV TVGAYGSLFN TIQALIDEGD EVILIVPFYD CYEPMVRMAG ATPVFIPLRS KPVYGKRWSS SDWTLDPQEL ESKFNSKTKA IILNTPHNPL GKVYNREELQ VIADLCIKYD TLCISDEVYE WLVYSGNKHL KIATFPGMWE RTITIGSAGK TFSVTGWKLG WSIGPNHLIK HLQTVQQNTI YTCATPLQEA LAQAFWIDIK RMDDPECYFN SLPKELEVKR DRMVRLLESV GLKPIVPDGG YFIIADVSLL DPDLSDMKNN EPYDYKFVKW MTKHKKLSAI PVSAFCNSET KSQFEKFVRF CFIKKDSTLD AAEEIIKAWS VQKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards