About Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (B3GNT6) is a protein
from Homo sapiens identified by UniProt accession
Q6ZMB0, 384 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase |
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| UniProt accession | Q6ZMB0 |
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| Gene | B3GNT6 |
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| Organism | Homo sapiens |
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| Length | 384 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (82)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- Rare pervasive developmental disorder · score 0.27
- glioblastoma multiforme · score 0.13
- cancer · score 0.05
- Autosomal recessive early-onset inflammatory bowel disease · score 0.04
- NK-cell enteropathy · score 0.04
- non-small cell lung carcinoma · score 0.04
- autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency · score 0.04
- gastrointestinal stromal tumor · score 0.04
- hereditary mixed polyposis syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZMB0-F1 | alphafold | PREDICTED | 86.85 | — |
Amino-acid sequence (384 residues)
MAFPCRRSLT AKTLACLLVG VSFLALQQWF LQAPRSPREE RSPQEETPEG PTDAPAADEP PSELVPGPPC VANASANATA DFEQLPARIQ DFLRYRHCRH FPLLWDAPAK CAGGRGVFLL LAVKSAPEHY ERRELIRRTW GQERSYGGRP VRRLFLLGTP GPEDEARAER LAELVALEAR EHGDVLQWAF ADTFLNLTLK HLHLLDWLAA RCPHARFLLS GDDDVFVHTA NVVRFLQAQP PGRHLFSGQL MEGSVPIRDS WSKYFVPPQL FPGSAYPVYC SGGGFLLSGP TARALRAAAR HTPLFPIDDA YMGMCLERAG LAPSGHEGIR PFGVQLPGAQ QSSFDPCMYR ELLLVHRFAP YEMLLMWKAL HSPALSCDRG HRVS
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