Transmembrane protein 184A (TMEM184A)

About Transmembrane protein 184A

Transmembrane protein 184A (TMEM184A) is a protein from Homo sapiens identified by UniProt accession Q6ZMB5, 413 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Transmembrane protein 184A
UniProt accession	Q6ZMB5
Gene	TMEM184A
Organism	Homo sapiens
Length	413 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.41
body height · score 0.31
blood protein measurement · score 0.09
appendicular lean mass · score 0.09
serum gamma-glutamyl transferase measurement · score 0.09
age at menarche · score 0.05
bone density · score 0.04
urate measurement · score 0.04
sex hormone-binding globulin measurement · score 0.03
age at first sexual intercourse measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZMB5-F1	alphafold	PREDICTED	72.19	—

Amino-acid sequence (413 residues)

MSNVSGILET AGVPLVSANW PQPSPPPAVP AGPQMDHMGN SSQGAPWLFL TSALARGVSG IFVWTALVLT CHQIYLHLRS YTVPQEQRYI IRLLLIVPIY AFDSWLSLLL LGDHQYYVYF DSVRDCYEAF VIYSFLSLCF QYLGGEGAIM AEIRGKPIKS SCLYGTCCLR GMTYSIGFLR FCKQATLQFC LVKPVMAVTT IILQAFGKYH DGDFNVRSGY LYVTLIYNAS VSLALYALFL FYFTTRELLR PFQPVLKFLT IKAVIFLSFW QGLLLAILER CGVIPEVETS GGNKLGAGTL AAGYQNFIIC VEMLFASVAL RYAFPCQVYA EKKENSPAPP APMQSISSGI RETVSPQDIV QDAIHNFSPA YQHYTQQATH EAPRPGTHPS GGSGGSRKSR SLEKRMLIPS EDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards