About Protein spinster homolog 3
Protein spinster homolog 3 (SPNS3) is a protein
from Homo sapiens identified by UniProt accession
Q6ZMD2, 512 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | Protein spinster homolog 3 |
|---|
| UniProt accession | Q6ZMD2 |
|---|
| Gene | SPNS3 |
|---|
| Organism | Homo sapiens |
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| Length | 512 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (29)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.17
- cortical thickness · score 0.16
- type 1 diabetes mellitus · score 0.16
- acute myeloid leukemia · score 0.08
- Congenital dyserythropoietic anemia type I · score 0.04
- Mayer-Rokitansky-Kuster-Hauser syndrome · score 0.04
- renal hypodysplasia/aplasia 3 · score 0.04
- kidney disease · score 0.03
- overhydrated hereditary stomatocytosis · score 0.03
- familial juvenile hyperuricemic nephropathy type 2 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZMD2-F1 | alphafold | PREDICTED | 84.46 | — |
Amino-acid sequence (512 residues)
MAGGMSAECP EPGPGGLQGQ SPGPGRQCPP PITPTSWSLP PWRAYVAAAV LCYINLLNYM NWFIIAGVLL DIQEVFQISD NHAGLLQTVF VSCLLLSAPV FGYLGDRHSR KATMSFGILL WSGAGLSSSF ISPRYSWLFF LSRGIVGTGS ASYSTIAPTV LGDLFVRDQR TRVLAVFYIF IPVGSGLGYV LGSAVTMLTG NWRWALRVMP CLEAVALILL ILLVPDPPRG AAETQGEGAV GGFRSSWCED VRYLGKNWSF VWSTLGVTAM AFVTGALGFW APKFLLEARV VHGLQPPCFQ EPCSNPDSLI FGALTIMTGV IGVILGAEAA RRYKKVIPGA EPLICASSLL ATAPCLYLAL VLAPTTLLAS YVFLGLGELL LSCNWAVVAD ILLSVVVPRC RGTAEALQIT VGHILGDAGS PYLTGLISSV LRARRPDSYL QRFRSLQQSF LCCAFVIALG GGCFLLTALY LERDETRAWQ PVTGTPDSND VDSNDLERQG LLSGAGASTE EP
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