PDZ domain-containing RING finger protein 4 (PDZRN4)

About PDZ domain-containing RING finger protein 4

PDZ domain-containing RING finger protein 4 (PDZRN4) is a protein from Homo sapiens identified by UniProt accession Q6ZMN7, 1036 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.

Target properties

Protein name	PDZ domain-containing RING finger protein 4
UniProt accession	Q6ZMN7
Gene	PDZRN4
Organism	Homo sapiens
Length	1036 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (75)

Diseases linked to this target (Open Targets).

body mass index · score 0.46
lean body mass · score 0.43
fat body mass · score 0.41
body fat percentage · score 0.40
alkaline phosphatase measurement · score 0.39
body weight · score 0.38
cortical thickness · score 0.36
cortical surface area measurement · score 0.36
type 2 diabetes mellitus · score 0.34
platelet count · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZMN7-F1	alphafold	PREDICTED	59.30	—

Amino-acid sequence (1036 residues)

MGFALERFAE AVDPALECKL CGQVLEEPLC TPCGHVFCAS CLLPWAVRRR RCPLQCQPLA PGELYRVLPL RSLIQKLRVQ CDYRARGCGH SVRLHELEAH VEHCDFGPAR RLRSRGGCAS GLGGGEVPAR GGCGPTPRAG RGGGARGGPP GGRWGRGRGP GPRVLAWRRR EKALLAQLWA LQGEVQLTAR RYQEKFTQYM AHVRNFVGDL GGGHRRDGEH KPFTIVLERE NDTLGFNIIG GRPNQNNQEG TSTEGIYVSK ILENGPADRA DGLEIHDKIM EVNGKDLSKA THEEAVEAFR NAKEPIVVQV LRRTPLSRPA YGMASEVQLM NASTQTDITF EHIMALAKLR PPTPPVPDIC PFLLSDSCHS LHPMEHEFYE DNEYISSLPA DADRTEDFEY EEVELCRVSS QEKLGLTVCY RTDDEEDTGI YVSEVDPNSI AAKDGRIREG DRILQINGED VQNREEAVAL LSNDECKRIV LLVARPEIQL DEGWLEDERN EFLEELNLEM LEEEHNEAMQ PTANEVEQPK KQEEEEGTTD TATSSSNNHE KDSGVGRTDE SLRNDESSEQ ENAAEDPNST SLKSKRDLGQ SQDTLGSVEL QYNESLVSGE YIDSDCIGNP DEDCERFRQL LELKCKIRNH GEYDLYYSSS TIECNQGEQE GVEHELQLLN EELRNIELEC QNIMQAHRLQ KVTDQYGDIW TLHDGGFRNY NTSIDMQRGK LDDIMEHPEK SDKDSSSAYN TAESCRSTPL TVDRSPDSSL PRVINLTNKK NLRSTMAATQ SSSGQSSKES TSTKAKTTEQ GCSAESKEKV LEGSKLPDQE KAVSEHIPYL SPYHSSSYRY ANIPAHARHY QSYMQLIQQK SAVEYAQSQL SLVSMCKESQ KCSEPKMEWK VKIRSDGTRY ITKRPVRDRI LKERALKIKE ERSGMTTDDD TMSEMKMGRY WSKEERKQHL VRAKEQRRRR EFMMRSRLEC LKESPQSGSE GKKEINIIEL SHKKMMKKRN KKILDNWMTI QELMTHGAKS PDGTRVHNAF LSVTTV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards