About Thrombospondin type-1 domain-containing protein 4
Thrombospondin type-1 domain-containing protein 4 (THSD4) is a protein
from Homo sapiens identified by UniProt accession
Q6ZMP0, 1018 residues long.
MolForge cross-references it against 0 known binders and
143 disease associations.
Target properties
| Protein name | Thrombospondin type-1 domain-containing protein 4 |
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| UniProt accession | Q6ZMP0 |
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| Gene | THSD4 |
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| Organism | Homo sapiens |
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| Length | 1018 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (143)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.52
- chronic obstructive pulmonary disease · score 0.50
- refractive error measurement · score 0.49
- familial thoracic aortic aneurysm and aortic dissection · score 0.48
- diastolic blood pressure · score 0.46
- forced expiratory volume · score 0.44
- peak expiratory flow · score 0.43
- cortical surface area measurement · score 0.42
- pulmonary function measurement · score 0.42
- smoking status measurement · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZMP0-F1 | alphafold | PREDICTED | 66.81 | — |
Amino-acid sequence (1018 residues)
MVSHFMGSLS VLCFLLLLGF QFVCPQPSTQ HRKVPQRMAA EGAPEDDGGG GAPGVWGAWG PWSACSRSCS GGVMEQTRPC LPRSYRLRGG QRPGAPARAF ADHVVSAVRT SVPLHRSRDE TPALAGTDAS RQGPTVLRGS RHPQPQGLEV TGDRRSRTRG TIGPGKYGYG KAPYILPLQT DTAHTPQRLR RQKLSSRHSR SQGASSARHG YSSPAHQVPQ HGPLYQSDSG PRSGLQAAEA PIYQLPLTHD QGYPAASSLF HSPETSNNHG VGTHGATQSF SQPARSTAIS CIGAYRQYKL CNTNVCPESS RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ AMGYRFYVRQ AEKVIDGTPC DQNGTAICVS GQCKSIGCDD YLGSDKVVDK CGVCGGDNTG CQVVSGVFKH ALTSLGYHRV VEIPEGATKI NITEMYKSNN YLALRSRSGR SIINGNWAID RPGKYEGGGT MFTYKRPNEI SSTAGESFLA EGPTNEILDV YMIHQQPNPG VHYEYVIMGT NAISPQVPPH RRPGEPFNGQ MVTEGRSQEE GEQKGRNEEK EDLRGEAPEM FTSESAQTFP VRHPDRFSPH RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRSTH EEAPESYCDS SMKPTPEEEP CNIFPCPAFW DIGEWSECSK TCGLGMQHRQ VLCRQVYANR SLTVQPYRCQ HLEKPETTST CQLKICSEWQ IRTDWTSCSV PCGVGQRTRD VKCVSNIGDV VDDEECNMKL RPNDIENCDM GPCAKSWFLT EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPA EATPCDNGPC TGKVEWFAGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPSECSFLEK PPSQQSCHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTLSNLC DPQLKPEERE SCNPQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC CASCTRVANR QTGFLGSR
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