Tripartite motif-containing protein 72 (TRIM72)

About Tripartite motif-containing protein 72

Tripartite motif-containing protein 72 (TRIM72) is a protein from Homo sapiens identified by UniProt accession Q6ZMU5, 477 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.

Target properties

Protein name	Tripartite motif-containing protein 72
UniProt accession	Q6ZMU5
Gene	TRIM72
Organism	Homo sapiens
Length	477 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (167)

Diseases linked to this target (Open Targets).

breast adenocarcinoma · score 0.18
neoplasm · score 0.10
diabetes mellitus · score 0.09
axial length measurement · score 0.08
hepatocellular carcinoma · score 0.08
coronary artery disease · score 0.07
breast cancer · score 0.07
exercise intolerance, riboflavin-responsive · score 0.07
acute myocardial infarction · score 0.07
Distal myopathy, Nonaka type · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZMU5-F1	alphafold	PREDICTED	90.68	—

Amino-acid sequence (477 residues)

MSAAPGLLHQ ELSCPLCLQL FDAPVTAECG HSFCRACLGR VAGEPAADGT VLCPCCQAPT RPQALSTNLQ LARLVEGLAQ VPQGHCEEHL DPLSIYCEQD RALVCGVCAS LGSHRGHRLL PAAEAHARLK TQLPQQKLQL QEACMRKEKS VAVLEHQLVE VEETVRQFRG AVGEQLGKMR VFLAALEGSL DREAERVRGE AGVALRRELG SLNSYLEQLR QMEKVLEEVA DKPQTEFLMK YCLVTSRLQK ILAESPPPAR LDIQLPIISD DFKFQVWRKM FRALMPALEE LTFDPSSAHP SLVVSSSGRR VECSEQKAPP AGEDPRQFDK AVAVVAHQQL SEGEHYWEVD VGDKPRWALG VIAAEAPRRG RLHAVPSQGL WLLGLREGKI LEAHVEAKEP RALRSPERRP TRIGLYLSFG DGVLSFYDAS DADALVPLFA FHERLPRPVY PFFDVCWHDK GKNAQPLLLV GPEGAEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards