About Beclin 1-associated autophagy-related key regulator
Beclin 1-associated autophagy-related key regulator (ATG14) is a protein
from Homo sapiens identified by UniProt accession
Q6ZNE5, 492 residues long.
MolForge cross-references it against 0 known binders and
93 disease associations.
Target properties
| Protein name | Beclin 1-associated autophagy-related key regulator |
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| UniProt accession | Q6ZNE5 |
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| Gene | ATG14 |
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| Organism | Homo sapiens |
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| Length | 492 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (93)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- COVID-19 · score 0.37
- lysosomal storage disease · score 0.37
- mean platelet volume · score 0.37
- blood protein measurement · score 0.27
- breast adenocarcinoma · score 0.18
- eosinophil count · score 0.17
- platelet count · score 0.15
- Testicular Germ Cell Tumor · score 0.11
- myeloid white cell count · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZNE5-F1 | alphafold | PREDICTED | 73.53 | — |
Amino-acid sequence (492 residues)
MASPSGKGAR ALEAPGCGPR PLARDLVDSV DDAEGLYVAV ERCPLCNTTR RRLTCAKCVQ SGDFVYFDGR DRERFIDKKE RLSRLKSKQE EFQKEVLKAM EGKWITDQLR WKIMSCKMRI EQLKQTICKG NEEMEKNSEG LLKTKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT IDLRSHYERL ANLRRSHILE LTSVIFPIEE VKTGVRDPAD VSSESDSAMT SSTVSKLAEA RRTTYLSGRW VCDDHNGDTS ISITGPWISL PNNGDYSAYY SWVEEKKTTQ GPDMEQSNPA YTISAALCYA TQLVNILSHI LDVNLPKKLC NSEFCGENLS KQKFTRAVKK LNANILYLCF SQHVNLDQLQ PLHTLRNLMY LVSPSSEHLG RSGPFEVRAD LEESMEFVDP GVAGESDESG DERVSDEETD LGTDWENLPS PRFCDIPSQS VEVSQSQSTQ ASPPIASSSA GGMISSAAAS VTSWFKAYTG HR
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