Lysosomal amino acid transporter 1 homolog (SLC66A1)

About Lysosomal amino acid transporter 1 homolog

Lysosomal amino acid transporter 1 homolog (SLC66A1) is a protein from Homo sapiens identified by UniProt accession Q6ZP29, 291 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	Lysosomal amino acid transporter 1 homolog
UniProt accession	Q6ZP29
Gene	SLC66A1
Organism	Homo sapiens
Length	291 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

Thyroid preparation use measurement · score 0.32
hypothyroidism · score 0.32
myxedema · score 0.20
appendicular lean mass · score 0.19
refractive error measurement · score 0.19
blood protein measurement · score 0.16
body height · score 0.15
lymphocyte count · score 0.14
heel bone mineral density · score 0.14
vital capacity · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZP29-F1	alphafold	PREDICTED	83.08	—

Amino-acid sequence (291 residues)

MVWKKLGSRN FSSCPSGSIQ WIWDVLGECA QDGWDEASVG LGLISILCFA ASTFPQFIKA YKTGNMDQAL SLWFLLGWIG GDSCNLIGSF LADQLPLQTY TAVYYVLADL VMLTLYFYYK FRTRPSLLSA PINSVLLFLM GMACATPLLS AAGPVAAPRE AFRGRALLSV ESGSKPFTRQ EVIGFVIGSI SSVLYLLSRL PQIRTNFLRK STQGISYSLF ALVMLGNTLY GLSVLLKNPE EGQSEGSYLL HHLPWLVGSL GVLLLDTIIS IQFLVYRRST AASELEPLLP S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards