About Transmembrane protein 182
Transmembrane protein 182 (TMEM182) is a protein
from Homo sapiens identified by UniProt accession
Q6ZP80, 229 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Transmembrane protein 182 |
|---|
| UniProt accession | Q6ZP80 |
|---|
| Gene | TMEM182 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 229 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (52)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.45
- PR interval · score 0.37
- neurodegenerative disease · score 0.34
- eosinophil count · score 0.29
- age at first sexual intercourse measurement · score 0.27
- smoking behavior · score 0.26
- age at first birth measurement · score 0.25
- diet measurement · score 0.24
- self reported educational attainment · score 0.24
- mathematical ability · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZP80-F1 | alphafold | PREDICTED | 87.50 | — |
Amino-acid sequence (229 residues)
MRLNIAIFFG ALFGALGVLL FLVAFGSDYW LLATEVGRCS GEKNIENVTF HHEGFFWRCW FNGIVEENDS NIWKFWYTNQ PPSKNCTHAY LSPYPFMRGE HNSTSYDSAV IYRGFWAVLM LLGVVAVVIA SFLIICAAPF ASHFLYKAGG GSYIAAGILF SLVVMLYVIW VQAVADMESY RNMKMKDCLD FTPSVLYGWS FFLAPAGIFF SLLAGLLFLV VGWHIQIHH
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