Coiled-coil domain-containing protein 141 (CCDC141)

About Coiled-coil domain-containing protein 141

Coiled-coil domain-containing protein 141 (CCDC141) is a protein from Homo sapiens identified by UniProt accession Q6ZP82, 1530 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.

Target properties

Protein name	Coiled-coil domain-containing protein 141
UniProt accession	Q6ZP82
Gene	CCDC141
Organism	Homo sapiens
Length	1530 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (67)

Diseases linked to this target (Open Targets).

pulse pressure measurement · score 0.43
heart rate · score 0.42
resting heart rate · score 0.41
Kallmann syndrome · score 0.37
diet measurement · score 0.37
diastolic blood pressure · score 0.35
maximal oxygen uptake measurement · score 0.34
heart rate response to recovery post exercise · score 0.34
arterial stiffness measurement · score 0.32
electrocardiography · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZP82-F1	alphafold	PREDICTED	71.78	—

Amino-acid sequence (1530 residues)

MSSQGSPSVA LSTTTVSSVA VQAGDSKIVI AVIKCGKWVQ LQLAESQPNL LEIGSSQDET KKLLHDHELL LAKLKALEDR VWELLQEADK TAEENKDQSQ VYDAMAETLG EAWAALVSML ERRTELLRLT SEFFENALEF AIKIDQAEDF LQNTHEFESA ESLKSLLQLH EHHTKELLER SLALLNKSQQ LTDFIEKFKC EGPNVNPELT QGAHSSCLKV DRLLELLQDR RRQLDKYLKQ QWQELSQVLQ ICQWDQQENQ VTCWFQKTIR NLQEQSLGSS LSDNEDRIHK QEELIIKAKE WNSAVEKLKS EALRILLSKD YVEKEHLQLS HQKLSQLQEE FGQLMVERNT WLKKANEFFN SANKAFDVLG RVEAYLKLLK SEGLSLAVLA VRHEELHRKI KDCTTDALQK GQTLISQVDS CSSQVSGIHE MMGCIKRRVD HLTEQCSAHK EYALKKQQLT ASVEGYLRKV EMSIQKISPV LSNAMDVGST RSESEKILNK YLELDIQAKE TSHELEAAAK TMMEKNEFVS DEMVSLSSKA RWLAEELNLF GQSIDYRSQV LQTYVAFLKS SEEVEMQFQS LKEFYETEIP QKEQDDAKAK HCSDSAEKQW QLFLKKSFIT QDLGLEFLNL INMAKENEIL DVKNEVYLMK NTMENQKAER EELSLLRLAW QLKATESKPG KQQWAAFKEQ LKKTSHNLKL LQEALMPVSA LDLGGSLQFI LDLRQKWNDM KPQFQQLNDE VQYIMKESEE LTGRGAPVKE KSQQLKDLIH FHQKQKERIQ DYEDILYKVV QFHQVKEELG RLIKSRELEF VEQPKELGDA HDVQIHLRCS QEKQARVDHL HRLALSLGVD IISSVQRPHC SNVSAKNLQQ QLELLEEDSM KWRAKAEEYG RTLSRSVEYC AMRDEINELK DSFKDIKKKF NNLKFNYTKK NEKSRNLKAL KYQIQQVDMY AEKMQALKRK MEKVSNKTSD SFLNYPSDKV NVLLEVMKDL QKHVDDFDKV VTDYKKNLDL TEHFQEVIEE CHFWYEDASA TVVRVGKYST ECKTKEAVKI LHQQFNKFIA PSVPQQEERI QEATDLAQHL YGLEEGQKYI EKIVTKHKEV LESVTELCES LTELEEKLKQ GDVLKMNPNL EDFHYDYIDL LKEPAKNKQT IFNEERNKGQ VQVADLLGIN GTGEERLPQD LKVSTDKEGG VQDLLLPEDM LSGEEYECVS PDDISLPPLP GSPESPLAPS DMEVEEPVSS SLSLHISSYG VQAGTSSPGD AQESVLPPPV AFADACNDKR ETFSSHFERP YLQFKAEPPL TSRGFVEKST ALHRISAEHP ESMMSEVHER ALQQHPQAQG GLLETREKMH ADNNFTKTQD RLHASSDAFS GLRFQSGTSR GYQRQMVPRE EIKSTSAKSS VVSLADQAPN FSRLLSNVTV MEGSPVTLEV EVTGFPEPTL TWYKKGQKLS ADGHLQVLHK ETRHSVFIPK VCKADAGLYV ARAQNSSGAL SSNVILHVTG NCRLPITRVN WITLCVVYVS VSLMYWLLTQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards