About Otogelin
Otogelin (OTOG) is a protein
from Homo sapiens identified by UniProt accession
Q6ZRI0, 2925 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Otogelin |
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| UniProt accession | Q6ZRI0 |
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| Gene | OTOG |
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| Organism | Homo sapiens |
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| Length | 2925 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (62)
Diseases linked to this target (Open Targets).
- hearing loss, autosomal recessive · score 0.66
- Rare genetic deafness · score 0.53
- Hearing impairment · score 0.44
- nonsyndromic genetic hearing loss · score 0.44
- deafness · score 0.42
- Vertigo · score 0.34
- autosomal dominant nonsyndromic hearing loss · score 0.27
- Seizure · score 0.27
- Intellectual disability · score 0.27
- vital capacity · score 0.20
3D Structure (9)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Amino-acid sequence (2925 residues)
MGVLASALCW LLCVWLPWGE QAAESLRVQR LGERVVDSGR SGARGMRNVK GMRNGPAQTR VSSSSSHQEA TLAMGDKATV VGGQQAEAPD SVAMSSWERR LHRAKCAPSY LFSCFNGGEC VHPAFCDCRR FNATGPRCQM VYNAGPERDS ICRAWGQHHV ETFDGLYYYL SGKGSYTLVG RHEPEGQSFS IQVHNDPQCG SSPYTCSRAV SLFFVGEQEI HLAKEVTHGG MRVQLPHVMG SARLQQLAGY VIVRHQSAFT LAWDGASAVY IKMSPELLGW THGLCGNNNA DPKDDLVTSS GKLTDDVVEF VHSWQEQAPN QPPGPTTSSL PRPPCLQQNP GTMQGVYEQC EALLRPPFDA CHAYVSPLPF TASCTSDLCQ SMGDVATWCR ALAEYARACA QAGRPLQGWR TQLRQCTVHC KEKAFTYNEC IACCPASCHP RASCVDSEIA CVDGCYCPNG LIFEDGGCVA PAECPCEFHG TLYPPGSVVK EDCNTCTCTS GKWECSTAVC PAECSVTGDI HFTTFDGRRY TFPATCQYIL AKSRSSGTFT VTLQNAPCGL NQDGACVQSV SVILHQDPRR QVTLTQAGDV LLFDQYKIIP PYTDDAFEIR RLSSVFLRVR TNVGVRVLYD REGLRLYLQV DQRWVEDTVG LCGTFNGNTQ DDFLSPVGVP ESTPQLFGNS WKTLSACSPL VSGSPLDPCD VHLQAASYSV QACSVLTGEM FAPCSAFLSP VPYFEQCRRD ACRCGQPCLC ATLAHYAHLC RRHGLPVDFR ARLPACALSC EASKEYSPCV APCGRTCQDL ASPEACGVDG GDDLSRDECV EGCACPPDTY LDTQADLCVP RNQCSCHFQG VDYPPGDSDI PSLGHCHCKD GVMSCDSRAP AAACPAGQVF VNCSDLHTDL ELSRERTCEQ QLLNLSVSAR GPCLSGCACP QGLLRHGDAC FLPEECPCTW KGKEYFPGDQ VMSPCHTCVC QRGSFQCTLH PCASTCTAYG DRHYRTFDGL PFDFVGACKV HLVKSTSDVS FSVIVENVNC YSSGMICRKF ISINVGNSLI VFDDDSGNPS PESFLDDKQE VHTWRVGFFT LVHFPQEHIT LLWDQRTTVH VQAGPQWQGQ LAGLCGNFDL KTINEMRTPE NLELTNPQEF GSSWAAVECP DTLDPRDMCV LNPLREPFAK KECSILLSEV FEICHPVVDV TWFYSNCLTD TCGCSQGGDC ECFCASVSAY AHQCCQHGVA VDWRTPRLCP YDCDFFNKVL GKGPYQLSSL AAGGALVGMK AVGDDIVLVR TEDVAPADIV SFLLTAALYK AKAHDPDVVS LEAADRPNFF LHVTANGSLE LAKWQGRDTF QQHASFLLHR GTRQAGLVAL ESLAKPSSFL YVSGAVLALR LYEHTEVFRR GTLFRLLDAK PSGAAYPICE WRYDACASPC FQTCRDPRAA SCRDVPRVEG CVPVCPTPQV LDEVTQRCVY LEDCVEPAVW VPTEALGNET LPPSQGLPTP SDEEPQLSQE SPRTPTHRPA LTPAAPLTTA LNPPVTATEE PVVSPGPTQT TLQQPLELTA SQLPAGPTES PASKGVTASL LAIPHTPESS SLPVALQTPT PGMVSGAMET TRVTVIFAGS PNITVSSRSP PAPRFPLMTK AVTVRGHGSL PVRTTPPQPS LTASPSSRPV ASPGAISRSP TSSGSHKAVL TPAVTKVISR TGVPQPTQAQ SASSPSTPLT VAGTAAEQVP VSPLATRSLE IVLSTEKGEA GHSQPMGSPA SPQPHPLPSA PPRPAQHTTM ATRSPALPPE TPAAASLSTA TDGLAATPFM SLESTRPSQL LSGLPPDTSL PLAKVGTSAP VATPGPKASV ITTPLQPQAT TLPAQTLSPV LPFTPAAMTQ AHPPTHIAPP AAGTAPGLLL GATLPTSGVL PVAEGTASMV SVVPRKSTTG KVAILSKQVS LPTSMYGSAE GGPTELTPAT SHPLTPLVAE PEGAQAGTAL PVPTSYALSR VSARTAPQDS MLVLLPQLAE AHGTSAGPHL AAEPVDEATT EPSGRSAPAL SIVEGLAEAL ATTTEANTST TCVPIAEQDC VRHICLEGQL IRVNQSQHCP QGAAPPRCGI LGLAVRVGGD RCCPLWECAC RCSIFPDLSF VTFDGSHVAL FKEAIYILSQ SPDEMLTVHV LDCKSANLGH LNWPPFCLVM LNMTHLAHQV TIDRFNRKVT VDLQPVWPPV SRYGFRIEDT GHMYMILTPS DIQIQWLHSS GLMIVEASKT SKAQGHGLCG ICDGDAANDL TLKDGSVVGG AEDPAPFLDS WQVPSSLTSV GQTRFRPDSC ATTDCSPCLR MVSNRTFSAC HRFVPPESFC ELWIRDTKYV QQPCVALTVY VAMCHKFHVC IEWRRSDYCP FLCSSDSTYQ ACVTACEPPK TCQDGILGPL DPEHCQVLGE GCVCSEGTIL HRRHSALCIP EAKCACTDSM GVPRALGETW NSSLSGCCQH QCQAPDTIVP VDLGCPSPRP ESCLRFGEVA LLLPTKDPCC LGTVCVCNQT LCEGLAPTCR PGHRLLTHFQ EDSCCPSYSC ECDPDLCEAE LVPSCRQDQI LITGRLGDSC CTSYFCACGD CPDSIPECQE GEALTVHRNT TELCCPLYQC VCENFRCPQV QCGLGTALVE VWSPDRCCPY KSCECDCDTI PVPRCHLWEK SQLDEEFMHS VENVCGCAKY ECVKAPVCLS RELGVMQPGQ TVVELSADGV CHTSRCTTVL DPLTNFYQIN TTSVLCDIHC EANQEYEHPR DLAACCGSCR NVSCLFTFPN GTTSLFLPGA SWIADCARHH CSSTPLGAVL VRSPISCPPL NETECAKVGG SVVPSLEGCC RTCKEDGRSC KKVTIRMTIR KNECRSSTPV NLVSCDGRCP SASIYNYNIN TYARFCKCCR EVGLQRRSVQ LFCATNATWV PYTVQEPTDC ACQWS
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