RNA-binding protein 43 (RBM43)

About RNA-binding protein 43

RNA-binding protein 43 (RBM43) is a protein from Homo sapiens identified by UniProt accession Q6ZSC3, 357 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	RNA-binding protein 43
UniProt accession	Q6ZSC3
Gene	RBM43
Organism	Homo sapiens
Length	357 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.41
antisocial behaviour measurement · score 0.27
attention deficit hyperactivity disorder · score 0.27
substance abuse · score 0.27
neurofibrillary tangles measurement · score 0.24
urinary metabolite measurement · score 0.22
tumor necrosis factor-inducible gene 6 protein measurement · score 0.19
type 2 diabetes mellitus · score 0.16
cortical surface area measurement · score 0.16
response to vaccine · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZSC3-F1	alphafold	PREDICTED	76.99	—

Amino-acid sequence (357 residues)

MASVLNVKES KAPERTVVVA GLPVDLFSDQ LLAVLVKSHF QDIKNEGGDV EDVIYPTRTK GVAYVIFKEK KVAENVIRQK KHWLARKTRH AELTVSLRVS HFGDKIFSSV NAILDLSVFG KEVTLETLVK DLKKKIPSLS FSPLKPNGRI SVEGSFLAVK RLRESLLARA CSLLEKDRNF TSEERKWNRQ NPQRNLQRSN NSLASVRTLV PETARSGEML VLDTDVFLYL KHKCGSYEST LKKFHILSQE KVDGEITTIC LKSIQVGSQP NNAKHVKELI EEWSHALYLK LRKETFILEG KENREKRMIK RACEQLSSRY LEVLINLYRT HIDIIGSSSD TYLFKKGVMK LIGQKVS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards