Zinc finger protein 621 (ZNF621)

About Zinc finger protein 621

Zinc finger protein 621 (ZNF621) is a protein from Homo sapiens identified by UniProt accession Q6ZSS3, 439 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Zinc finger protein 621
UniProt accession	Q6ZSS3
Gene	ZNF621
Organism	Homo sapiens
Length	439 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

arterial stiffness measurement · score 0.23
PHF-tau measurement · score 0.22
colorectal cancer · score 0.19
neurodegenerative disease · score 0.19
colorectal adenoma · score 0.13
blood protein measurement · score 0.13
polyp of colon · score 0.13
metabolite measurement · score 0.11
drug use measurement · score 0.11
heel bone mineral density · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ZSS3-F1	alphafold	PREDICTED	62.98	—

Amino-acid sequence (439 residues)

MLQTTWPQES VTFEDVAVYF TQNQWASLDP AQRALYGEVM LENYANVASL VAFPFPKPAL ISHLERGEAP WGPDPWDTEI LRGISQGGES WIKNEGLVIK QEASEETELH RMPVGGLLRN VSQHFDFKRK ALKQTFNLNP NLILRGGMKF YECKECGKIF RYNSKLIRHQ MSHTGEKPFK CKECGKAFKS SYDCIVHEKN HIGEGPYECK ECGKGLSSNT ALTQHQRIHT GEKPYECKEC GKAFRRSAAY LQHQRLHTGE KLYKCKECWK AFGCRSLFIV HQRIHTGEKP YQCKECGKAF TQKIASIQHQ RVHTGEKPYE CKVCGKAFKW YGSFVQHQKL HPVEKKPVKV LGPSLVSPQC SSPAIPPVLL QGSCSASAVA VPSLTFPHAV LIPTSGNFFM LLPTSGIPSS SAQIVRVFQG LTPTVKPSPV ILTPSSHSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards