About Tumor protein p63-regulated gene 1 protein
Tumor protein p63-regulated gene 1 protein (TPRG1) is a protein
from Homo sapiens identified by UniProt accession
Q6ZUI0, 275 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | Tumor protein p63-regulated gene 1 protein |
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| UniProt accession | Q6ZUI0 |
|---|
| Gene | TPRG1 |
|---|
| Organism | Homo sapiens |
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| Length | 275 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (78)
Diseases linked to this target (Open Targets).
- bone density · score 0.31
- urate measurement · score 0.31
- PHF-tau measurement · score 0.20
- body height · score 0.14
- lymphocyte count · score 0.11
- eosinophil count · score 0.11
- asthma · score 0.11
- Eczematoid dermatitis · score 0.10
- eosinophil percentage of leukocytes · score 0.10
- allergic rhinitis · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ZUI0-F1 | alphafold | PREDICTED | 73.74 | — |
Amino-acid sequence (275 residues)
MSTIGSFEGF QAVSLKQEGD DQPSETDHLS MEEEDPMPRQ ISRQSSVTES TLYPNPYHQP YISRKYFATR PGAIETAMED LKGHVAETSG ETIQGFWLLT KIDHWNNEKE RILLVTDKTL LICKYDFIML SCVQLQRIPL SAVYRICLGK FTFPGMSLDK RQGEGLRIYW GSPEEQSLLS RWNPWSTEVP YATFTEHPMK YTSEKFLEIC KLSGFMSKLV PAIQNAHKNS TGSGRGKKLM VLTEPILIET YTGLMSFIGN RNKLGYSLAR GSIGF
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